Park Young Min, Lee Sang Min, Kim Dong Won, Shin Sung-Chan, Lee Byung-Joo
Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea.
Department of Otorhinolaryngology, Bundang Jesaeng Hospital, Deajin Medical Center, Seongnam, Gyeonggi, Korea.
PLoS One. 2017 May 17;12(5):e0177956. doi: 10.1371/journal.pone.0177956. eCollection 2017.
We performed this retrospective study to identify predictors of right paraesophageal lymph node metastasis, and reviewed previous studies related to this topic.
Between June 2005 and March 2015, 1107 patients were diagnosed with papillary thyroid carcinoma and underwent surgery at Pusan National University Hospital.
Right paraesophageal lymph node metastasis was observed in 171 (15.4%) patients. Multivariate analyses showed that the risk of right paraesophageal metastasis was significantly associated with tumor size, location, a higher number of metastatic central lymph nodes, and lateral lymph node metastasis. In a meta-analysis of the eligible studies, tumor size, number of metastatic central lymph nodes, and lateral lymph node metastasis showed significant relationships with the risk of right paraesophageal metastasis.
In patients with risk factors such as those identified in our study, the possibility of right paraesophageal metastasis should be kept in mind, and careful inspection and dissection are required.
我们开展这项回顾性研究以确定右食管旁淋巴结转移的预测因素，并回顾了此前与此主题相关的研究。
2005年6月至2015年3月期间，1107例患者被诊断为乳头状甲状腺癌，并在釜山国立大学医院接受了手术。
171例（15.4%）患者出现右食管旁淋巴结转移。多因素分析显示，右食管旁转移风险与肿瘤大小、位置、中央淋巴结转移数量较多以及侧方淋巴结转移显著相关。在对符合条件的研究进行的荟萃分析中，肿瘤大小、中央淋巴结转移数量以及侧方淋巴结转移与右食管旁转移风险显示出显著关系。
对于存在如我们研究中所确定的危险因素的患者，应牢记右食管旁转移的可能性，并且需要仔细检查和清扫。
