[Age-related changes in Na,K-ATPase activity of the plasma membrane of kidney cells and erythrocytes in spontaneously hypertensive and normotensive rats].

The Na,K-ATPase activity and sensitivity to ouabain in kidney and erythrocytes of spontaneously hypertensive (SHR) and normotensive rats (Wistar-Kyoto and Wistar) of different age, were studied. The enzyme activity in cortex of kidney of SHR and WKY of any age were lower than that in cortex of Wistar rats. In 1.5-month rats the enzyme activity in cortex of SHR was lower than that of WKY and higher in 3-month animals. Weanling rats of every line had a decreased sensitivity of Na, K-ATPase to ouabain in cortex and medulla of kidney as compared to erythrocyte enzyme but with ageing it increased and reached the erythrocyte level. The possible role of Na,K-ATPase in pathogenesis of primary hypertension is discussed.