Peskin A V, Konstantinov A A, Zbarsky I B
N.K. Koltzov Institute of Developmental Biology Acad. Sci USSR, Moscow.
Free Radic Res Commun. 1987;3(1-5):47-55. doi: 10.3109/10715768709069769.
Nuclear membranes from many tumors contain an unusual redox chain discovered originally in the Hepatoma 22a nuclear membranes which catalyzes superoxide dismutase-sensitive adrenaline oxidation to adrenochrome in the presence of either NADPH or NADH as electron donor, the reaction being inhibited by cyanide and azide. This redox chain can reduce anthracycline antitumor antibiotics adriamycin and carminomycin to their free radical states under anaerobic conditions. Evidence has been obtained for a higher stability of the carminomycin radical as compared to that of adriamycin. Operation of the nuclear membrane-bound redox chain can be a source of oxygen radical-mediated single strand breaks in DNA. The role of the nuclear membrane-associated electron transfer chain in augmenting the anticancer action of the anthracycline antibiotics is discussed.
许多肿瘤的核膜含有一种不同寻常的氧化还原链，最初是在肝癌22a核膜中发现的。在以NADPH或NADH作为电子供体的情况下，该氧化还原链可催化超氧化物歧化酶敏感的肾上腺素氧化为肾上腺色素，该反应受氰化物和叠氮化物抑制。在厌氧条件下，这种氧化还原链可将蒽环类抗肿瘤抗生素阿霉素和洋红霉素还原为自由基状态。已有证据表明，洋红霉素自由基比阿霉素自由基具有更高的稳定性。与核膜结合的氧化还原链的作用可能是DNA中氧自由基介导的单链断裂的一个来源。本文讨论了核膜相关电子传递链在增强蒽环类抗生素抗癌作用中的作用。
