Li Jing, Sun Fei, Chen Zhe, Yang Yunjiao, Zhao Jiuliang, Li Mengtao, Tian Xinping, Zeng Xiaofeng
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, 100032, China.
Arthritis Res Ther. 2017 May 25;19(1):107. doi: 10.1186/s13075-017-1307-z.
We aimed to investigate the clinical characteristics of 411 Chinese Takayasu's arteritis (TAK) patients using a retrospective analysis.
We retrospectively reviewed 810 medical charts of patients with a diagnosis of TAK who were admitted to Peking Union Medical College Hospital from 1990 to 2014. 411 patients with a complete dataset were finally included in the analysis. The demographic data, clinical features, angiographic patterns, and TAK-related surgical procedures were collected and analyzed.
The median age at disease onset was 23 (18, 30) years old, with a median disease duration of 21 (6, 60) months; 325 (79.1%) were female. The angiographic involvement pattern was type I in 91 (22.1%) patients, type IIa in 16 (3.9%) patients, type IIb in 16 (3.9%) patients, type III in 12 (2.9%) patients, type IV in 26 (6.3%) patients, and type V in 250 (60.8%) patients. Subclavian arteries (79.8%) were the most commonly involved, followed by carotid arteries (79.1%). The occurrence rate (4.1%) of aortic aneurysm in this study was low; 119 operations and interventions were performed. The most common cause of death in this study was heart failure.
Subclavian arteries, carotid arteries, and type V were the most frequently involved arteries and angiography pattern in this Chinese TAK study. The difference in angiographic features may lead to differences in clinical manifestations. Surgical operation and interventions should be performed at different stages of the disease course.
我们旨在通过回顾性分析来研究411例中国大动脉炎（TAK）患者的临床特征。
我们回顾性查阅了1990年至2014年在北京协和医院住院的810例诊断为TAK患者的病历。最终纳入分析的是411例具有完整数据集的患者。收集并分析了人口统计学数据、临床特征、血管造影模式以及与TAK相关的外科手术。
发病时的中位年龄为23（18，30）岁，中位病程为21（6，60）个月；325例（79.1%）为女性。血管造影受累模式：I型91例（22.1%），IIa型16例（3.9%），IIb型16例（3.9%），III型12例（2.9%），IV型26例（6.3%），V型250例（60.8%）。锁骨下动脉（79.8%）是最常受累的血管，其次是颈动脉（79.1%）。本研究中主动脉瘤的发生率较低（4.1%）；共进行了119次手术和干预。本研究中最常见的死亡原因是心力衰竭。
在这项中国TAK研究中，锁骨下动脉、颈动脉和V型是最常受累的血管和血管造影模式。血管造影特征的差异可能导致临床表现的差异。应在病程的不同阶段进行外科手术和干预。
