Department of Rheumatology, Rigshospitalet, Copenhagen, Denmark.
Clin Exp Rheumatol. 2011 Jan-Feb;29(1 Suppl 64):S40-2. Epub 2011 May 11.
To evaluate the annual incidence of Takayasu's arteritis (TA) in eastern Denmark and to describe the clinical course of Danish TA patients.
All patients living in the eastern part of Denmark and registered with a first-time hospital discharge diagnosis of TA between 1990 and 2009 were identified. The TA diagnoses of the identified patients were confirmed by medical records review.
A total of 19 TA patients (3 males and 16 females) were included in the study. Two patients were of Asian origin, while 17 were Caucasians. The median patient age at the time of the TA diagnosis was 36 years (range: 19-66 years), and the median time interval between the onset of symptoms attributable to TA and the diagnosis of the disease was 11 months (range: 1-50 months). The estimated mean annual incidence of TA was 0.4 (95% CI: 0.25-0.62) per million. No deaths occurred during a median follow-up period of 11.5 years (range: 0.5-19.5 years). Eleven patients (58%) experienced one or more serious vascular events due to TA. Among these, eight patients developed their vascular complications before the vasculitis diagnosis was established.
In the current cohort, serious vascular events affected a large proportion of patients before the TA diagnosis was made or during follow-up. The incidence of TA in Denmark seems to be comparable to the incidence in other regions of Europe.
评估丹麦东部 Takayasu 动脉炎（TA）的年发病率，并描述丹麦 TA 患者的临床病程。
确定在 1990 年至 2009 年间首次因医院出院诊断为 TA 而居住在丹麦东部的所有患者。通过病历回顾来确认确定患者的 TA 诊断。
共纳入 19 例 TA 患者（3 名男性和 16 名女性）。两名患者为亚洲人，而 17 名患者为白种人。TA 诊断时患者的中位年龄为 36 岁（范围：19-66 岁），症状归因于 TA 与疾病诊断之间的中位时间间隔为 11 个月（范围：1-50 个月）。TA 的估计平均年发病率为 0.4（95%CI：0.25-0.62）/百万。在中位数为 11.5 年（范围：0.5-19.5 年）的随访期间无死亡发生。11 名患者（58%）经历了一次或多次由 TA 引起的严重血管事件。其中，有 8 名患者在血管炎诊断确立之前发生了血管并发症。
在当前队列中，在做出 TA 诊断之前或随访期间，严重的血管事件影响了很大一部分患者。丹麦 TA 的发病率似乎与欧洲其他地区的发病率相当。
