Chettinad Academy of Research & Education (CARE), Kelambakkam, Chennai 603103, TN, India.
Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600 036, TN, India.
Drug Discov Today. 2017 Aug;22(8):1224-1232. doi: 10.1016/j.drudis.2017.05.006. Epub 2017 May 22.
Despite advances in treatment modalities, colon cancer (CC) is the third most common cause of cancer-related death worldwide. Subsequent unfavorable effects owing to toxicity of conventional drugs are a challenging problem associated with chemotherapy. There is noticeable concern toward site-specific/targeted delivery of chemotherapeutic drugs specifically to the affected site of the colon in a predictable and reproducible manner. However, the biggest challenge in successful drug targeting for the colon is avoidance of drug absorption and/or degradation in the upper gastrointestinal tract before the drug reaches the colon. Nanoparticles endowed with targeting abilities offer a novel approach for site-specific delivery of chemotherapeutic agents. The present review focuses on recent approaches for colon-specific drug delivery (CDDS) and aims to unveil the emerging possibilities and advances in the treatment of CC with CDDS.
尽管治疗方法有所进步，但结肠癌 (CC) 仍是全球癌症相关死亡的第三大主要原因。由于常规药物的毒性，随后产生的不良影响是与化疗相关的一个具有挑战性的问题。人们明显关注的是，以可预测和可重复的方式将化疗药物特异性地递送到结肠的特定部位/靶向部位。然而，成功将药物靶向结肠的最大挑战是避免药物在上消化道被吸收和/或降解，直到药物到达结肠。具有靶向能力的纳米颗粒为化疗药物的靶向递药提供了一种新方法。本综述重点介绍了用于结肠特异性药物递送 (CDDS) 的最新方法，并旨在揭示 CDDS 在治疗 CC 方面的新兴可能性和进展。
