Chen An-Chih, Shyu Ling-Yuh, Hsin Yue-Loong, Chen Ke-Min, Lai Shih-Chan
Department of Neurology, Chung-Shan Medical University Hospital, Taichung 402, Taiwan.
Department of Parasitology, Chung Shan Medical University, Taichung 402, Taiwan.
Acta Trop. 2017 Sep;173:76-84. doi: 10.1016/j.actatropica.2017.05.023. Epub 2017 May 22.
Resveratrol, a natural herbal compound found in high levels in grapes and red wine, is frequently used as activator of sirtuin-1. This study investigated the potential function of sirtuin-1 in regulating angiostrongyliasis meningoencephalitis in resveratrol-treated mice. Mice were subjected to meningoencephalitis to study the protective effect of resveratrol against meningoencephalitis and investigate the effects of sirtuin-1 activation on brain. Results demonstrated that sirtuin-1 level decreased in mice with meningoencephalitis and significantly increased in resveratrol-treated mice. Moreover, resveratrol treatment significantly reduced eosinophil counts, p65, Interferon-γ, interleukin (IL)-5, IL-33, and tumor necrosis factor-α levels, matrix metalloproteinase-9 activity, claudin-5 degradation, and blood-brain barrier permeability. By contrast, the anti-inflammatory factor IL-10 was significantly increased in resveratrol-treated mice. Resveratrol treatment was partially beneficial in controlling the pathological processes of angiostrongyliasis meningoencephalitis. The results demonstrate the neuroprotective and anti-inflammatory effects of resveratrol against Angiostrongylus cantonensis-induced eosinophilic meningoencephalitis in mice. Treatment with sirtuin-1 agonist was given within a therapeutic window after A. cantonensis infection.
白藜芦醇是一种在葡萄和红酒中含量很高的天然草本化合物，常被用作沉默信息调节因子1（sirtuin-1）的激活剂。本研究调查了sirtuin-1在调节白藜芦醇治疗的小鼠脑脊髓炎中的潜在作用。使小鼠患上脑脊髓炎，以研究白藜芦醇对脑脊髓炎的保护作用，并调查sirtuin-1激活对大脑的影响。结果表明，脑脊髓炎小鼠的sirtuin-1水平降低，而白藜芦醇治疗的小鼠中sirtuin-1水平显著升高。此外，白藜芦醇治疗显著降低了嗜酸性粒细胞计数、p65、干扰素-γ、白细胞介素（IL）-5、IL-33和肿瘤坏死因子-α水平、基质金属蛋白酶-9活性、claudin-5降解以及血脑屏障通透性。相比之下，白藜芦醇治疗的小鼠中抗炎因子IL-10显著增加。白藜芦醇治疗在控制脑脊髓炎的病理过程中部分有益。结果证明了白藜芦醇对小鼠广州管圆线虫诱导的嗜酸性粒细胞性脑脊髓炎具有神经保护和抗炎作用。在广州管圆线虫感染后的治疗窗口期内给予sirtuin-1激动剂治疗。
