Institute of Medical Sciences, Tzu Chi University, Hualien 97004, Taiwan.
Department of Biochemistry, School of Medicine, Tzu Chi University, Hualien 97004, Taiwan.
Biomolecules. 2020 Jul 5;10(7):1001. doi: 10.3390/biom10071001.
A Currently, infections are predominantly treated with albendazole. However, the use of albendazole can provoke certain neurological symptoms as a result of the immune response triggered by the dead worms. Therefore, treatment usually involves co-administration of corticosteroids to limit the inflammatory reaction. Corticosteroids play a useful role in suppressing inflammation in the brain; however, long-term usage or high dosage may make it problematic.Schisandrin B, an active ingredient from , has been shown to have anti-inflammatory effects on the brain. This study aimed to investigate the effects and potential of schisandrin B in combination with albendazole to treat -induced meningoencephalitis. Here, we show that albendazole-schisandrin B co-treatment suppressed neuroinflammation in -infected mice and increased the survival of the mice. Accordingly, albendazole-schisandrin B co-treatment significantly inhibited inflammasome activation, pyroptosis, and apoptosis. The sensorimotor functions of the mice were also repaired after albendazole-schisandrin B treatment. Immune response was shown to shift from Th2 to Th1, which reduces inflammation and enhances immunity against . Collectively, our study showed that albendazole-schisandrin B co-therapy may be used as an encouraging treatment for -induced meningoencephalitis.
目前，感染主要用阿苯达唑治疗。然而，阿苯达唑的使用会由于死虫引发的免疫反应而引发某些神经症状。因此，治疗通常涉及联合使用皮质类固醇来限制炎症反应。皮质类固醇在抑制大脑炎症方面发挥了有用的作用；然而，长期使用或高剂量可能会导致问题。五味子素 B 是五味子中的一种活性成分，已被证明对大脑具有抗炎作用。本研究旨在探讨五味子素 B 与阿苯达唑联合治疗弓形虫引起的脑膜脑炎的效果和潜力。在这里，我们表明阿苯达唑-五味子素 B 联合治疗抑制了弓形虫感染小鼠的神经炎症，并提高了小鼠的存活率。相应地，阿苯达唑-五味子素 B 联合治疗显著抑制了炎症小体激活、细胞焦亡和细胞凋亡。阿苯达唑-五味子素 B 治疗后，小鼠的感觉运动功能也得到了修复。免疫反应显示从 Th2 向 Th1 转变，这减轻了炎症并增强了对弓形虫的免疫力。总之，我们的研究表明，阿苯达唑-五味子素 B 联合治疗可能是一种有希望的治疗弓形虫引起的脑膜脑炎的方法。
