da Silva Filho Tiago João, de Oliveira Denise Hélen Imaculada Pereira, Brasil Veruska Lima Moura, Nonaka Cassiano Francisco Weege, da Silveira Éricka Janine Dantas, Queiroz Lélia Maria Guedes
Postgraduate Program, Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Postgraduate Program, Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Exp Mol Pathol. 2017 Aug;103(1):9-13. doi: 10.1016/j.yexmp.2017.05.014. Epub 2017 May 22.
To evaluate cases diagnosed as "oral hemangiomas" based on the immunohistochemical expression of human glucose transporter protein (GLUT-1) and on histopathological features, and to investigate whether the classification proposed by the ISSVA was used correctly to classify these lesions.
All cases stored in the archives of an Oral Pathology Service and diagnosed as "oral hemangiomas" were reviewed. Seventy-seven cases were analyzed regarding the expression of GLUT-1. GLUT-1(+) specimens were classified as true infantile hemangioma (IH) and GLUT-1(-) specimens were reclassified based on their histopathological features. The nomenclature of these lesions was evaluated and some cases were reclassified.
Only 26 (33.8%) of the specimens were indeed IHs. Among the GLUT-1(-) specimens, 20 (26.0%) were reclassified as pyogenic granulomas (PGs) and 31 (40.2%) as vascular malformations. Considering the previously applied nomenclature, only 47.5% of the cases initially diagnosed as "hemangiomas" were IHs. In the group of "capillary hemangiomas", most cases (56.2%) were PGs. Among the three "cellular hemangiomas", two were PGs and one was IH. Most (88.8%) "cavernous hemangiomas" were vascular malformations.
Careful and parameterized review of cases of vascular anomalies is necessary using auxiliary tools such as GLUT-1, since the exclusive use of histopathological findings might be insufficient to differentiate some anomalies.
Accurate clinical examination and the use of biomarkers such as GLUT-1 are essential for the diagnosis.
基于人类葡萄糖转运蛋白（GLUT-1）的免疫组化表达和组织病理学特征，对诊断为“口腔血管瘤”的病例进行评估，并调查国际血管畸形研究学会（ISSVA）提出的分类方法是否被正确用于这些病变的分类。
回顾了存储在口腔病理科档案中诊断为“口腔血管瘤”的所有病例。分析了77例病例中GLUT-1的表达情况。GLUT-1(+)标本被分类为真性婴儿血管瘤（IH），GLUT-1(-)标本根据其组织病理学特征重新分类。评估了这些病变的命名法，并对一些病例进行了重新分类。
仅26例（33.8%）标本为真性IH。在GLUT-1(-)标本中，20例（26.0%）被重新分类为化脓性肉芽肿（PG），31例（40.2%）被重新分类为血管畸形。考虑到先前应用的命名法，最初诊断为“血管瘤”的病例中只有47.5%为IH。在“毛细血管瘤”组中，大多数病例（56.2%）为PG。在三个“细胞性血管瘤”中，两个为PG，一个为IH。大多数（88.8%）“海绵状血管瘤”为血管畸形。
使用GLUT-1等辅助工具对血管异常病例进行仔细且参数化的回顾是必要的，因为仅使用组织病理学结果可能不足以区分某些异常。
准确的临床检查和使用GLUT-1等生物标志物对诊断至关重要。
