糖尿病性视网膜病变中的经典Wnt信号通路。
Canonical Wnt signaling in diabetic retinopathy.
作者信息
Chen Qian, Ma Jian-Xing
机构信息
Department of Physiology, Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States.
Department of Physiology, Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States.
出版信息
Vision Res. 2017 Oct;139:47-58. doi: 10.1016/j.visres.2017.02.007. Epub 2017 Jun 2.
Abstract
Diabetic retinopathy (DR) is a common eye complication of diabetes, and the pathogenic mechanism of DR is still under investigation. The canonical Wnt signaling pathway is an evolutionarily conserved pathway that plays fundamental roles in embryogenesis and adult tissue homeostasis. Wnt signaling regulates expression of multiple genes that control retinal development and eye organogenesis, and dysregulated Wnt signaling plays pathophysiological roles in many ocular diseases, including DR. This review highlights recent progress in studies of Wnt signaling in DR. We discuss Wnt signaling regulation in the retina and dysregulation of Wnt signaling associated with ocular diseases with an emphasis on DR. We also discuss the therapeutic potential of modulating Wnt signaling in DR. Continued studies in this field will advance our current understanding on DR and contribute to the development of new treatments.
摘要
糖尿病视网膜病变（DR）是糖尿病常见的眼部并发症，其发病机制仍在研究中。经典Wnt信号通路是一条在进化上保守的通路，在胚胎发育和成年组织稳态中发挥着重要作用。Wnt信号调节多个控制视网膜发育和眼器官发生的基因的表达，而失调的Wnt信号在包括DR在内的许多眼部疾病中发挥病理生理作用。本综述重点介绍了DR中Wnt信号研究的最新进展。我们讨论了视网膜中的Wnt信号调节以及与眼部疾病相关的Wnt信号失调，重点是DR。我们还讨论了调节DR中Wnt信号的治疗潜力。该领域的持续研究将推动我们目前对DR的理解，并有助于开发新的治疗方法。
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