Reiss C S, Chen S S, Huang A S, Doherty R
Division of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115.
Microb Pathog. 1986 Jun;1(3):261-7. doi: 10.1016/0882-4010(86)90050-1.
Mice immunized with vesicular stomatitis virus (VSV), with its glycoprotein (G) in lipid vesicles or with a truncated, soluble form of G called Gs, developed an expanded population of virus specific cytolytic T lymphocyte (CTL) precursors and also led to the production of neutralizing serum antibody. The CTL precursors could be restimulated in vitro with either the virus or its glycoprotein components. Thus the glycoprotein of VSV, either associated with lipids or in soluble form, induced both cellular and humoral immune responses that might be sufficient to result in protective immunity.
用水疱性口炎病毒（VSV）、脂质囊泡中的其糖蛋白（G）或一种名为Gs的截短的可溶性G形式免疫的小鼠，产生了扩大的病毒特异性细胞毒性T淋巴细胞（CTL）前体细胞群，并且还导致了中和性血清抗体的产生。CTL前体细胞可以在体外被病毒或其糖蛋白成分再次刺激。因此，VSV的糖蛋白，无论是与脂质结合还是以可溶形式存在，都能诱导细胞免疫和体液免疫反应，这些反应可能足以产生保护性免疫。
