GPR75 Identified as the First 20-HETE Receptor: A Chemokine Receptor Adopted by a New Family.
作者信息
Fan Fan, Roman Richard J
机构信息
From the Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson.
出版信息
Circ Res. 2017 May 26;120(11):1696-1698. doi: 10.1161/CIRCRESAHA.117.311022.
Abstract
摘要
相似文献
1
GPR75 Identified as the First 20-HETE Receptor: A Chemokine Receptor Adopted by a New Family.GPR75被鉴定为首个20-羟基二十碳四烯酸受体：一个被新家族采用的趋化因子受体。
Circ Res. 2017 May 26;120(11):1696-1698. doi: 10.1161/CIRCRESAHA.117.311022.
2
20-HETE Signals Through G-Protein-Coupled Receptor GPR75 (G) to Affect Vascular Function and Trigger Hypertension.20-羟基二十碳四烯酸（20-HETE）通过G蛋白偶联受体GPR75发出信号，影响血管功能并引发高血压。
Circ Res. 2017 May 26;120(11):1776-1788. doi: 10.1161/CIRCRESAHA.116.310525. Epub 2017 Mar 21.
3
The CYP/20-HETE/GPR75 axis in hypertension.高血压中的 CYP/20-HETE/GPR75 轴。
Adv Pharmacol. 2022;94:1-25. doi: 10.1016/bs.apha.2022.02.003. Epub 2022 Mar 30.
4
Uncovering the signalling, structure and function of the 20-HETE-GPR75 pairing: Identifying the chemokine CCL5 as a negative regulator of GPR75.揭示 20-HETE-GPR75 配对的信号转导、结构和功能：鉴定趋化因子 CCL5 为 GPR75 的负调节剂。
Br J Pharmacol. 2021 Sep;178(18):3813-3828. doi: 10.1111/bph.15525. Epub 2021 Jun 15.
5
20-Hydroxyeicosatetraenoic acid (20-HETE): Bioactions, receptors, vascular function, cardiometabolic disease and beyond.20-羟二十碳四烯酸（20-HETE）：生物活性、受体、血管功能、心血管代谢疾病及其他。
Adv Pharmacol. 2023;97:229-255. doi: 10.1016/bs.apha.2023.01.002. Epub 2023 Feb 24.
6
Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid.源自花生四烯酸的羟基二十碳四烯酸（HETEs）和氧代二十碳四烯酸（oxo-ETEs）的生物合成、生物学效应及受体
Biochim Biophys Acta. 2015 Apr;1851(4):340-55. doi: 10.1016/j.bbalip.2014.10.008. Epub 2014 Oct 29.
7
RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75.调节激活正常T细胞表达和分泌的因子（RANTES）可刺激转染G蛋白偶联受体75的细胞中的钙离子动员和三磷酸肌醇（IP3）形成。
Br J Pharmacol. 2006 Nov;149(5):490-7. doi: 10.1038/sj.bjp.0706909. Epub 2006 Sep 25.
8
Activation of neuronal transient receptor potential vanilloid 1 channel underlies 20-hydroxyeicosatetraenoic acid-induced vasoactivity: role for protein kinase A.神经元瞬时受体电位香草酸 1 通道的激活是 20-羟基二十碳四烯酸诱导血管活性的基础：蛋白激酶 A 的作用。
Hypertension. 2013 Aug;62(2):426-33. doi: 10.1161/HYPERTENSIONAHA.111.00942. Epub 2013 Jun 10.
9
Fenofibrate Attenuates Hypertension in Goldblatt Hypertensive Rats: Role of 20-Hydroxyeicosatetraenoic Acid in the Nonclipped Kidney.非诺贝特减轻Goldblatt高血压大鼠的高血压：20-羟基二十碳四烯酸在未夹闭肾脏中的作用
Am J Med Sci. 2017 Jun;353(6):568-579. doi: 10.1016/j.amjms.2017.04.009. Epub 2017 Apr 12.
10
[Role of androgens in the renal production of 20-hydroxyeicosatetraenoic acid in spontaneously hypertensive rats].[雄激素在自发性高血压大鼠肾脏生成20-羟基二十碳四烯酸中的作用]
Nihon Jinzo Gakkai Shi. 2004 Oct;46(7):685-92.
引用本文的文献
1
The curious family of cytochrome P450 4F fatty acid ω-hydroxylases: recent developments in their function and relevance for human health.细胞色素P450 4F脂肪酸ω-羟化酶的奇特家族：其功能及与人类健康相关性的最新进展
Open Biol. 2025 Aug;15(8):250115. doi: 10.1098/rsob.250115. Epub 2025 Aug 27.
2
Donor Age Impairs Vasculogenic Potential of hiPSC-Derived Endothelial Progenitors.供体年龄损害人诱导多能干细胞衍生的内皮祖细胞的血管生成潜能。
bioRxiv. 2025 Jun 27:2025.06.24.661422. doi: 10.1101/2025.06.24.661422.
3
CYP1A1/20-HETE/GPR75 Axis-Mediated Arachidonic Acid Metabolism Dysregulation in H-Type Hypertension Pathogenesis.CYP1A1/20-羟基二十碳四烯酸/GPR75轴介导的花生四烯酸代谢失调在H型高血压发病机制中的作用
Int J Mol Sci. 2025 Jun 20;26(13):5947. doi: 10.3390/ijms26135947.
4
Collateral is brain: Low perfusion triggers spreading depolarization and futile reperfusion after acute ischemic stroke.侧支循环是大脑：急性缺血性脑卒中后低灌注引发扩散性去极化和无效再灌注。
J Cereb Blood Flow Metab. 2024 Oct;44(10):1881-1887. doi: 10.1177/0271678X241270480. Epub 2024 Sep 3.
5
20-HETE and Hypertension.20-羟基二十碳四烯酸与高血压
Hypertension. 2024 Oct;81(10):2012-2015. doi: 10.1161/HYPERTENSIONAHA.124.21718. Epub 2024 Aug 28.
6
Drug development advances in human genetics-based targets.基于人类遗传学靶点的药物研发进展。
MedComm (2020). 2024 Feb 9;5(2):e481. doi: 10.1002/mco2.481. eCollection 2024 Feb.
7
G Protein-Coupled Receptor 75 (GPR75) As a Novel Molecule for Targeted Therapy of Cancer and Metabolic Syndrome.G 蛋白偶联受体 75（GPR75）作为癌症和代谢综合征靶向治疗的新分子。
Asian Pac J Cancer Prev. 2023 May 1;24(5):1817-1825. doi: 10.31557/APJCP.2023.24.5.1817.
8
20-Hydroxyeicosatetraenoic acid (20-HETE): Bioactions, receptors, vascular function, cardiometabolic disease and beyond.20-羟二十碳四烯酸（20-HETE）：生物活性、受体、血管功能、心血管代谢疾病及其他。
Adv Pharmacol. 2023;97:229-255. doi: 10.1016/bs.apha.2023.01.002. Epub 2023 Feb 24.
9
Mice deficient for G-protein-coupled receptor 75 display altered presynaptic structural protein expression and disrupted fear conditioning recall.G 蛋白偶联受体 75 缺失的小鼠表现出突触前结构蛋白表达改变和恐惧条件反射记忆缺失。
J Neurochem. 2023 Jun;165(6):827-841. doi: 10.1111/jnc.15818. Epub 2023 Apr 21.
10
Metabolite G-Protein Coupled Receptors in Cardio-Metabolic Diseases.代谢物 G 蛋白偶联受体在心脏代谢疾病中的作用。
Cells. 2021 Nov 29;10(12):3347. doi: 10.3390/cells10123347.
本文引用的文献
1
20-HETE Signals Through G-Protein-Coupled Receptor GPR75 (G) to Affect Vascular Function and Trigger Hypertension.20-羟基二十碳四烯酸（20-HETE）通过G蛋白偶联受体GPR75发出信号，影响血管功能并引发高血压。
Circ Res. 2017 May 26;120(11):1776-1788. doi: 10.1161/CIRCRESAHA.116.310525. Epub 2017 Mar 21.
2
Recent developments on the vascular effects of 20-hydroxyeicosatetraenoic acid.20-羟基二十碳四烯酸血管效应的最新进展
Curr Opin Nephrol Hypertens. 2017 Mar;26(2):74-82. doi: 10.1097/MNH.0000000000000302.
3
Molecular mechanisms and cell signaling of 20-hydroxyeicosatetraenoic acid in vascular pathophysiology.20-羟二十碳四烯酸在血管病理生理学中的分子机制和细胞信号转导。
Front Biosci (Landmark Ed). 2016 Jun 1;21(7):1427-63. doi: 10.2741/4465.
4
Vascular actions of 20-HETE.20-羟基二十碳四烯酸的血管作用
Prostaglandins Other Lipid Mediat. 2015 Jul;120:9-16. doi: 10.1016/j.prostaglandins.2015.03.002. Epub 2015 Mar 23.
5
Cytochrome P450 eicosanoids in hypertension and renal disease.高血压和肾脏疾病中的细胞色素P450类花生酸
Curr Opin Nephrol Hypertens. 2015 Jan;24(1):37-46. doi: 10.1097/MNH.0000000000000088.
6
The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis.新型趋化因子受体 G 蛋白偶联受体 75 由胰岛表达，并与胰岛素分泌刺激和改善葡萄糖内稳态相关联。
Diabetologia. 2013 Nov;56(11):2467-76. doi: 10.1007/s00125-013-3022-x. Epub 2013 Aug 27.
7
Protein kinase C pharmacology: refining the toolbox.蛋白激酶 C 药理学：完善工具盒。
Biochem J. 2013 Jun 1;452(2):195-209. doi: 10.1042/BJ20130220.
8
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.20-羟基二十碳四烯酸（20-HETE）通过表皮生长因子受体（EGFR）和c-Src依赖性机制激活肾上皮细胞中的Raf/丝裂原活化蛋白激酶/细胞外信号调节激酶（Raf/MEK/ERK）信号通路。
Am J Physiol Renal Physiol. 2009 Sep;297(3):F662-70. doi: 10.1152/ajprenal.00146.2009. Epub 2009 Jul 1.
9
Synergistic activation of vascular TRPC6 channel by receptor and mechanical stimulation via phospholipase C/diacylglycerol and phospholipase A2/omega-hydroxylase/20-HETE pathways.受体和机械刺激通过磷脂酶C/二酰基甘油以及磷脂酶A2/ω-羟化酶/20-羟基二十碳四烯酸途径对血管瞬时受体电位通道6（TRPC6）进行协同激活。
Circ Res. 2009 Jun 19;104(12):1399-409. doi: 10.1161/CIRCRESAHA.108.193227. Epub 2009 May 14.
10
Effect of 20-HETE inhibition on infarct volume and cerebral blood flow after transient middle cerebral artery occlusion.20-羟基二十碳四烯酸（20-HETE）抑制对短暂性大脑中动脉闭塞后梗死体积和脑血流量的影响。
J Cereb Blood Flow Metab. 2009 Mar;29(3):629-39. doi: 10.1038/jcbfm.2008.156. Epub 2008 Dec 24.
Zotero 插件