20-羟基二十碳四烯酸与高血压
20-HETE and Hypertension.
作者信息
Roman Richard J
机构信息
Department of Pharmacology, University of Mississippi Medical Center, Jackson, MS.
出版信息
Hypertension. 2024 Oct;81(10):2012-2015. doi: 10.1161/HYPERTENSIONAHA.124.21718. Epub 2024 Aug 28.
Abstract
Previous studies established that arachidonic acid is metabolized by the cytochrome P450 (CYP) enzymes of the 4A and 4F families to 20-hydroxyeicosatetraenoic (20-HETE) that regulates renal function and vascular tone. Elevations in the 20-HETE have been reported to increase blood pressure by promoting endothelial dysfunction, vascular inflammation, oxidative stress and endothelial expression of angiotensin-converting enzyme, which increase circulating angiotensin II levels. However, mutations in and that inhibit the formation of 20-HETE have been linked to hypertension in human genetic studies, and a deficiency in 20-HETE promotes sodium retention and hypertension in Dahl salt-sensitive rats. This Perspective focuses on knowledge gaps concerning the pro- versus anti-hypertensive actions of 20-HETE and the GPR75/20-HETE receptor in mediating these effects.
摘要
先前的研究表明，花生四烯酸被4A和4F家族的细胞色素P450（CYP）酶代谢为20-羟基二十碳四烯酸（20-HETE），后者调节肾功能和血管张力。据报道，20-HETE水平升高会通过促进内皮功能障碍、血管炎症、氧化应激和血管紧张素转换酶的内皮表达来升高血压，进而增加循环中的血管紧张素II水平。然而，在人类遗传学研究中，抑制20-HETE形成的[具体基因名称缺失]和[具体基因名称缺失]突变与高血压有关，并且在 Dahl 盐敏感大鼠中，20-HETE缺乏会促进钠潴留和高血压。本观点聚焦于关于20-HETE的降压与升压作用以及GPR75/20-HETE受体在介导这些效应方面的知识空白。
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