Elbahlawan Lama, Rains K Jason, Stokes Dennis C
Division of Critical Care, Department of Pediatric Medicine.
Respiratory Therapy Department and Intensive Care Unit, St Jude Children's Research Hospital, Memphis, Tennessee.
Respir Care. 2017 Jun;62(6):765-775. doi: 10.4187/respcare.05223.
This article reviews the common pulmonary complications seen in the pediatric oncology population and our approach to diagnosis, management, and therapy considerations in this specialized population, including patients receiving chemotherapy, radiation, and hematopoietic stem cell transplantation. Although infections cause the most significant complications in this population, non-infectious complications, including acute lung injury from chemotherapy or radiation, idiopathic interstitial pneumonia, diffuse alveolar hemorrhage, bronchiolitis obliterans, and cryptogenic organizing pneumonia, also occur commonly. With improvements in survival of childhood cancer, there are now a growing number of adults who are childhood cancer survivors who may be encountered by therapists in adult hospitals. We also review the growing literature on the emerging late pulmonary findings in these adult childhood cancer survivors.
本文回顾了儿科肿瘤患者中常见的肺部并发症,以及我们针对这一特殊人群的诊断、管理和治疗考量方法,其中包括接受化疗、放疗和造血干细胞移植的患者。虽然感染是该人群中最主要的并发症,但非感染性并发症,如化疗或放疗引起的急性肺损伤、特发性间质性肺炎、弥漫性肺泡出血、闭塞性细支气管炎和隐源性机化性肺炎,也很常见。随着儿童癌症生存率的提高,现在成年医院的治疗师会遇到越来越多曾患儿童癌症的成年幸存者。我们还回顾了关于这些成年儿童癌症幸存者中不断出现的晚期肺部表现的越来越多的文献。