不同抗糖尿病治疗策略对肥胖2型糖尿病患者氧化应激标志物的影响。
Effect of variable antidiabetic treatments strategy on oxidative stress markers in obese patients with T2DM.
作者信息
ALrefai Abeer A, Alsalamony Alsayed M, Fatani Sameer H, Kamel Hala F M
机构信息
Medical Biochemistry Department, Faculty of Medicine, Menoufia University, Shebîn El Kôm, Egypt.
Department of Internal Medicine, Diabetes and Endocrinology Unit, Mansoura University, Mansoura, Egypt.
出版信息
Diabetol Metab Syndr. 2017 May 25;9:27. doi: 10.1186/s13098-017-0220-6. eCollection 2017.
AIM
To evaluate the effect of different anti-diabetic treatment strategy on oxidative stress markers in patients with type 2 diabetes mellitus (T2DM).
SUBJECT AND METHODS
A total of 93 patients with T2DM treated with metformin (G1 = 25), OHA (G2 = 22), OA and insulin (G3 = 26) and insulin alone (G4 = 20). In all patients, lipid profile and glycemic indices were assessed using routine laboratory tests. MDA and Oxidized LDL were assessed using commercially available ELISA kits. Laboratory tests were performed at baseline and at a control visit after 24 weeks of treatment.
RESULTS
A significant decrease in the levels of MDA with improvement of glycemic control was observed in the group receiving OHA in combination with insulin therapy. A similar decrease of oxLDL was observed in all diabetic subgroups with borderline significance in those receiving metformin alone. The remaining clinical and biochemical parameters were not changed during follow-up in any of the involved groups.
CONCLUSION
A combination therapy with insulin was more effective in glycemic control and MDA reduction in T2DM. Whereas, a significant oxLDLc reduction was observed in T2DM irrespective of categories of antidiabetic treatment or glycemic control.
目的
评估不同抗糖尿病治疗策略对2型糖尿病（T2DM）患者氧化应激标志物的影响。
对象与方法
共有93例T2DM患者，分别接受二甲双胍治疗（G1 = 25例）、口服降糖药（OHA）治疗（G2 = 22例）、OHA与胰岛素联合治疗（G3 = 26例）以及单纯胰岛素治疗（G4 = 20例）。所有患者均通过常规实验室检查评估血脂谱和血糖指标。使用市售酶联免疫吸附测定（ELISA）试剂盒评估丙二醛（MDA）和氧化型低密度脂蛋白（Oxidized LDL）。在基线及治疗24周后的对照访视时进行实验室检查。
结果
在接受OHA联合胰岛素治疗的组中，随着血糖控制的改善，MDA水平显著降低。在所有糖尿病亚组中均观察到氧化型低密度脂蛋白（oxLDL）有类似降低，在单纯接受二甲双胍治疗的患者中具有临界显著性。在随访期间，所有相关组的其余临床和生化参数均未改变。
结论
胰岛素联合治疗在T2DM患者的血糖控制和MDA降低方面更有效。然而，无论抗糖尿病治疗类别或血糖控制情况如何，T2DM患者的氧化型低密度脂蛋白胆固醇（oxLDLc）均显著降低。
Zotero 插件