通过级联羟醛缩合/半缩酮化反应合成D-庚酮糖。
Synthesis of D--heptulose via a cascade aldol/hemiketalization reaction.
作者信息
Chen Yan, Wang Xiaoman, Wang Junchang, Yang You
机构信息
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
出版信息
Beilstein J Org Chem. 2017 Apr 28;13:795-799. doi: 10.3762/bjoc.13.79. eCollection 2017.
Abstract
A [4 + 3] synthesis of D--heptulose is described. The cascade aldol/hemiketalization reaction of a C aldehyde with a C ketone provides the differentially protected ketoheptose building block, which can be further reacted to furnish target D--heptulose.
摘要
描述了一种D-庚酮糖的[4 + 3]合成方法。一个C醛与一个C酮的级联羟醛缩合/半缩酮化反应提供了差异保护的酮庚糖结构单元，该结构单元可进一步反应以得到目标D-庚酮糖。
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