Department of Chemistry, Indian Institute of Technology Guwahati , North Guwahati, Assam 781039, India.
Org Lett. 2017 Feb 3;19(3):662-665. doi: 10.1021/acs.orglett.6b03823. Epub 2017 Jan 25.
An organocatalytic asymmetric cascade Michael/hemiketalization/retro-aldol reaction between unsaturated pyrazolones and α-nitroketones is described. A bifunctional thiourea catalyst was found to be efficient for this reaction. With 10 mol % of catalyst, high yields as well as excellent enantioselectivities are attained for a variety of 3-acyloxy pyrazoles under mild reaction conditions.
一种有机催化不对称级联迈克尔/半缩醛化/反醛缩醇反应被描述为不饱和吡唑酮和α-硝基酮之间的反应。研究发现双功能硫脲催化剂对此反应具有高效性。在温和的反应条件下，使用 10 mol%的催化剂，对于各种 3-酰氧基吡唑，可获得高产率和优异的对映选择性。
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