Haussmann Mark F, Vleck Carol M
Department of Zoology and Genetics, Iowa State University, Ames, Iowa, 50011, USA.
Oecologia. 2002 Feb;130(3):325-328. doi: 10.1007/s00442-001-0827-y. Epub 2002 Feb 1.
Field biologists often work with animals for which there is no prior history. A marker of an animal's age would offer insight into how age and experience affect reproductive success and other life history parameters. Telomere length shortens with age in cultured cells and mouse and human tissues. We found that lengths of telomere restriction fragments cleaved from blood cell DNA shorten predictably with age in the zebra finch (Taeniopygia guttata). If this relationship holds in other species, it should be possible, once the relationship between telomere length and age has been determined for a given species, to use blood samples to estimate ages of free-living animals. This will allow the incorporation of age into estimates of factors affecting life history parameters in cases where previous histories of animals are unknown.
野外生物学家经常研究那些没有过往记录的动物。动物年龄的一个标志物将有助于深入了解年龄和经验如何影响繁殖成功率及其他生活史参数。在培养细胞以及小鼠和人类组织中,端粒长度会随着年龄增长而缩短。我们发现,从斑胸草雀(Taeniopygia guttata)血细胞DNA中切割出的端粒限制片段的长度会随着年龄的增长而呈可预测的缩短。如果这种关系在其他物种中也成立,那么一旦确定了某一特定物种中端粒长度与年龄之间的关系,就应该可以利用血液样本估计自由生活动物的年龄。这将使得在动物过往历史未知的情况下,能够将年龄纳入影响生活史参数的因素估计中。