不等弯孢菌钒氯过氧化物酶催化烯烃的卤代官能团化反应
Halofunctionalization of alkenes by vanadium chloroperoxidase from Curvularia inaequalis.
作者信息
Dong Jia Jia, Fernández-Fueyo Elena, Li Jingbo, Guo Zheng, Renirie Rokus, Wever Ron, Hollmann Frank
机构信息
Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands.
出版信息
Chem Commun (Camb). 2017 Jun 6;53(46):6207-6210. doi: 10.1039/c7cc03368k.
PMID:28548142
Abstract
The vanadium-dependent chloroperoxidase from Curvularia inaequalis is a stable and efficient biocatalyst for the hydroxyhalogenation of a broad range of alkenes into halohydrins. Up to 1 200 000 TON with 69 s TOF were observed for the biocatalyst. A bienzymatic cascade to yield epoxides as reaction products is presented.
摘要
不等弯孢霉的钒依赖性氯过氧化物酶是一种稳定且高效的生物催化剂，可将多种烯烃羟基卤化为卤代醇。该生物催化剂的TON高达1200000，TOF为69秒。本文介绍了一种以环氧化物为反应产物的双酶级联反应。
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