Comuzzie Anthony G, Blangero John, Mahaney Michael C, Mitchell Braxton D, Stern Michael P, Maccluer Jean W
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78228.
Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78228.
Am J Hum Biol. 1993;5(6):725-734. doi: 10.1002/ajhb.1310050616.
A variance decomposition analysis using maximum likelihood methods was employed to examine the genetic architecture of sexual dimorphism in anthropometric traits in a large pedigreed sample of Mexican American individuals from San Antonio, Texas. For this analysis the magnitude of sexual dimorphism was viewed as arising from a special case of genotype by environment interaction (G × E), that of genotype by sex (G × S). Evidence indicates a marked G × S interaction for 9 of the 12 traits examined and 1 of the 4 indices, findings which are interpreted as indicators of a strong genetic component to the degree of sexual dimorphism expressed in these traits. Such results have important implications for the use and interpretation of these traits in an epidemiological as well as an evolutionary context. © 1993 Wiley-Liss, Inc.
利用最大似然法进行方差分解分析，以研究来自得克萨斯州圣安东尼奥的墨西哥裔美国人的大型系谱样本中人体测量特征的性二态性的遗传结构。在该分析中，性二态性的大小被视为由基因型与环境相互作用（G×E）的一种特殊情况，即基因型与性别的相互作用（G×S）产生。证据表明，在所研究的12个性状中的9个以及4个指标中的1个存在显著的G×S相互作用，这些发现被解释为这些性状中表现出的性二态性程度具有强大遗传成分的指标。这些结果对于在流行病学以及进化背景下使用和解释这些性状具有重要意义。© 1993威利 - 利斯公司。
