Valeev A E, Chernevskaia N I, Dzhakhangirov F N, Israilov I A, Iunusov M S
Neirofiziologiia. 1988;20(6):820-3.
Experiments on isolated neurons of sensory ganglions of rats aimed to find physiologically active plant drugs were carried out by means of voltage-clamp, intracellular perfusion and "concentration-clamp" methods. Izokorin was shown to exert blocking action on GABA-activated currents as bicuculline and korlumin. It is suggested that other bicuculline-like alkaloids corresponding to isomers can exert the same effect on GABA-activated currents.
利用电压钳、细胞内灌注和“浓度钳”方法，对大鼠感觉神经节的离体神经元进行了旨在寻找具有生理活性的植物药物的实验。结果表明，异可卡林与荷包牡丹碱和科鲁明一样，对γ-氨基丁酸（GABA）激活电流具有阻断作用。有人提出，与异构体相对应的其他荷包牡丹碱样生物碱可能对GABA激活电流产生相同的作用。
