[Gaba-activated conductance of isolated neurons of rat cerebellum and sensory ganglia].

Results of the study of GABA-activated ion currents on single isolated neurons of rat were obtained by means of voltage-clamp, intracellular perfusion and "concentration clamp" methods. The reversion potential of GABA-activated current corresponded to the equilibrium potential for Cl ions as it was determined by the Nernst equation. The dose-response relationship was activated by a single GABA molecule (Kd = 1.4.10(-4) mol/l). GABA-activated currents were blocked by bicuculline methoiodide and isocoryne.