Valeev A E, Chernevskaia N I
Neirofiziologiia. 1988;20(5):645-52.
Results of the study of GABA-activated ion currents on single isolated neurons of rat were obtained by means of voltage-clamp, intracellular perfusion and "concentration clamp" methods. The reversion potential of GABA-activated current corresponded to the equilibrium potential for Cl ions as it was determined by the Nernst equation. The dose-response relationship was activated by a single GABA molecule (Kd = 1.4.10(-4) mol/l). GABA-activated currents were blocked by bicuculline methoiodide and isocoryne.
通过电压钳、细胞内灌注和“浓度钳”方法，获得了对大鼠单个分离神经元上γ-氨基丁酸（GABA）激活离子电流的研究结果。GABA激活电流的反转电位与氯离子的平衡电位相对应，这是由能斯特方程确定的。剂量反应关系由单个GABA分子激活（解离常数Kd = 1.4×10⁻⁴摩尔/升）。GABA激活电流被碘化甲基荷包牡丹碱和异紫堇碱阻断。
