State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 345 Lingling Lu, Shanghai 200032, People's Republic of China.
Org Lett. 2017 Jun 16;19(12):3307-3310. doi: 10.1021/acs.orglett.7b01469. Epub 2017 May 26.
A gold-catalyzed formal [3 + 2] cycloaddition of ynamides with 4,5-dihydro-1,2,4-oxadiazoles has been developed. The reaction provides a concise and regioselective access to highly functionalized 4-aminoimidazoles likely via the formation of an α-imino gold carbene intermediate followed by cyclization. 4,5-Dihydro-1,2,4-oxadiazole was found to act as an efficient N-iminonitrene equivalent in these reactions.
发展了一种金催化的炔酰胺与 4,5-二氢-1,2,4-噁二唑的[3+2]环加成反应。该反应通过形成α-亚氨基金卡宾中间体，随后环化，提供了一种简洁且区域选择性的方法来合成高官能化的 4-氨基咪唑。在这些反应中，发现 4,5-二氢-1,2,4-噁二唑是一种有效的 N-亚氨基氮烯等价物。
