Xu Wei, Chen Yulong, Wang Ali, Liu Yuanhong
State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis , Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 345 Lingling Lu , Shanghai 200032 , People's Republic of China.
Org Lett. 2019 Sep 20;21(18):7613-7618. doi: 10.1021/acs.orglett.9b02893. Epub 2019 Sep 10.
An efficient gold-catalyzed [3 + 2] annulation of benzofurazan -oxides with ynamides has been developed, which provides a concise and regioselective access to highly functionalized 7-nitroindoles. Although -oxides are often considered as oxygen transfer reagents in gold catalysis, benzofurazan -oxide was found to act as a facile precursor for an α-imino gold carbene intermediate. Benzofurazan can also react with ynamides to afford quinoxaline -oxides via a [4 + 2] annulation process.
已开发出一种高效的金催化苯并呋咱氧化物与烯酰胺的[3+2]环化反应，该反应为高度官能团化的7-硝基吲哚提供了一种简洁且区域选择性的合成方法。尽管氧化物在金催化中常被视为氧转移试剂，但发现苯并呋咱氧化物是α-亚氨基金卡宾中间体的便捷前体。苯并呋咱还可与烯酰胺反应，通过[4+2]环化过程生成喹喔啉氧化物。
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