Yasmin Memona, Rakha Allah, Noreen Saadia, Salahuddin Zeenat
University of Health Sciences, Khayaban-e-Jamia Punjab, Lahore 54600, Pakistan.
Leg Med (Tokyo). 2017 May;26:11-13. doi: 10.1016/j.legalmed.2017.02.001. Epub 2017 Feb 8.
The entire mitochondrial DNA control region (nt 16024-576) of 88 unrelated individuals of Sindhi ethnic group residing in different parts of Sindh province of Pakistan was sequenced. Out of 66 different observed haplotypes 50 were unique and 16 were shared by more than one individual. Results showed admixture of mtDNA pool constituting the haplogroups derived mainly from South Asia (47.6%) and West Eurasian (35.7%) whereas the contribution of the African haplogroup was very small (2.4%). High values of genetic diversity (0.992), power of discrimination (0.981) and low value of random match probability (0.018) indicates that mtDNA analysis for this population can effectively be used for forensic casework. The results are valuable contribution towards building mtDNA population variation database for this particular ethnic group from Pakistan.
对居住在巴基斯坦信德省不同地区的88名不相关的信德族个体的整个线粒体DNA控制区（核苷酸16024 - 576）进行了测序。在观察到的66种不同单倍型中，50种是独特的，16种被不止一个个体共享。结果显示线粒体DNA库存在混合情况，主要由源自南亚（47.6%）和西欧亚（35.7%）的单倍群组成，而非洲单倍群的贡献非常小（2.4%）。高遗传多样性值（0.992）、鉴别力（0.981）和低随机匹配概率值（0.018）表明，该人群的线粒体DNA分析可有效地用于法医案件工作。这些结果对建立来自巴基斯坦这个特定族群的线粒体DNA群体变异数据库做出了有价值的贡献。
