Department of Neurology, Affiliated Zhong Da Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
J Alzheimers Dis. 2017;58(4):1283-1292. doi: 10.3233/JAD-161286.
Early diagnosis and effective management are pivotal steps in preventing the transition from mild cognitive impairment (MCI) to Alzheimer's disease. Previous investigations indicated that some event-related potential (ERP) components in MCI are sensitive to cognitive decline. However, several comparative analyses of these components in MCI and healthy controls (HC) yielded inconsistent results.
The aim was to perform a systematic review and meta-analysis of ERP studies on MCI patients.
We systematically searched on PubMed and Web of Science for MCI-related ERP studies published from April 1986 to August 2016. Standard mean difference estimates of all components were compared between MCI and HC.
Our study showed increased P50 amplitude at the Cz site; reduced N2pc amplitude and delayed P200 latency at the Cz site; N200 latency at the Cz and Pz sites, and P300 latency at the Cz and Pz sites in MCI patients compared to HC.
In summary, our study indicated that some ERP components, such as P50 and N2pc amplitude, P200, N200, and P300 latency might be potential electrophysiological biomarkers for MCI diagnosis.
早期诊断和有效管理是预防轻度认知障碍（MCI）向阿尔茨海默病转化的关键步骤。先前的研究表明，MCI 中的一些事件相关电位（ERP）成分对认知下降敏感。然而，对 MCI 和健康对照组（HC）中这些成分的几项比较分析得出的结果并不一致。
对 MCI 患者的 ERP 研究进行系统回顾和荟萃分析。
我们系统地在 PubMed 和 Web of Science 上搜索了 1986 年 4 月至 2016 年 8 月发表的与 MCI 相关的 ERP 研究。比较 MCI 和 HC 之间所有成分的标准均数差估计值。
我们的研究表明，与 HC 相比，MCI 患者在 Cz 部位的 P50 振幅增加；在 Cz 部位的 N2pc 振幅降低和 P200 潜伏期延迟；在 Cz 和 Pz 部位的 N200 潜伏期和 Cz 和 Pz 部位的 P300 潜伏期。
总之，我们的研究表明，一些 ERP 成分，如 P50 和 N2pc 振幅、P200、N200 和 P300 潜伏期，可能是 MCI 诊断的潜在电生理生物标志物。
