一种由源自印度尼西亚海鞘的白双轮青霉产生的新型联苯醚衍生物。
A new biphenyl ether derivative produced by Indonesian ascidian-derived Penicillium albobiverticillium.
作者信息
Sumilat Deiske A, Yamazaki Hiroyuki, Endo Kotaro, Rotinsulu Henki, Wewengkang Defny S, Ukai Kazuyo, Namikoshi Michio
机构信息
Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, 981-8558, Japan.
Faculty of Fisheries and Marine Science, Sam Ratulangi University, Kampus Bahu, Manado, 95115, Indonesia.
出版信息
J Nat Med. 2017 Oct;71(4):776-779. doi: 10.1007/s11418-017-1094-5. Epub 2017 May 26.
A new biphenyl ether derivative, 2-hydroxy-6-(2'-hydroxy-3'-hydroxymethyl-5-methylphenoxy)-benzoic acid (1), was isolated together with the known benzophenone derivative, monodictyphenone (2), from a culture broth of Indonesian ascidian-derived Penicillium albobiverticillium TPU1432 by solvent extraction, ODS column chromatography, and preparative HPLC (ODS). The structure of 1 was elucidated based on NMR experiments. Compound 2 exhibited moderate inhibitory activities against protein tyrosine phosphatase (PTP) 1B, T cell PTP (TCPTP), and CD45 tyrosine phosphatase (CD45), whereas compound 1 modestly inhibited CD45 activity.
通过溶剂萃取、ODS柱色谱法和制备型高效液相色谱（ODS），从印度尼西亚海鞘来源的白轮枝青霉TPU1432的培养液中分离出一种新的联苯醚衍生物2-羟基-6-(2'-羟基-3'-羟甲基-5-甲基苯氧基)苯甲酸（1），以及已知的二苯甲酮衍生物单迪卡酮（2）。基于核磁共振实验阐明了化合物1的结构。化合物2对蛋白酪氨酸磷酸酶（PTP）1B、T细胞PTP（TCPTP）和CD45酪氨酸磷酸酶（CD45）表现出中等抑制活性，而化合物1对CD45活性有适度抑制作用。
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