来自南极海洋真菌青霉属菌株S-1-18的呋喃酮衍生物和倍半萜

Furanone derivative and sesquiterpene from Antarctic marine-derived fungus Penicillium sp. S-1-18.

作者信息

Zhou Yue, Li Yun-Hai, Yu Hao-Bing, Liu Xiao-Yu, Lu Xiao-Ling, Jiao Bing-Hua

机构信息

a Marine Biopharmaceutical Institute , Second Military Medical University , Shanghai 200433 , China.

b Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences , Second Military Medical University , Shanghai 200433 , China.

出版信息

J Asian Nat Prod Res. 2018 Dec;20(12):1108-1115. doi: 10.1080/10286020.2017.1385604. Epub 2017 Oct 9.

DOI:10.1080/10286020.2017.1385604

PMID:28990801

Abstract

A new furanone derivative, butanolide A (1), and a new sesquiterpene, guignarderemophilane F (2), together with six known compounds, were isolated from the fungus Penicillium sp. S-1-18 derived from Antarctic marine. The new structures were determined by spectroscopic studies such as 1D- and 2D-NMR and MS analyses. The absolute configuration of 1 was determined by the modified Mosher's method, while the absolute configuration of 2 was determined by calculated ECD spectroscopy. The isolated secondary metabolites were evaluated for their protein tyrosine phosphatase 1B (PTP1B) inhibitory activity. Compound 1 showed moderate inhibitory activity against PTP1B with IC value of 27.4 μM.

摘要

从源自南极海洋的青霉菌 Penicillium sp. S-1-18 中分离出一种新的呋喃酮衍生物丁醇内酯 A（1）、一种新的倍半萜吉纳德瑞莫菲兰 F（2）以及六种已知化合物。通过 1D 和 2D-NMR 以及 MS 分析等光谱研究确定了新结构。1 的绝对构型通过改良的莫舍尔方法确定，而 2 的绝对构型通过计算电子圆二色光谱确定。对分离得到的次生代谢产物进行了蛋白酪氨酸磷酸酶 1B（PTP1B）抑制活性评估。化合物 1 对 PTP1B 表现出中等抑制活性，IC 值为 27.4 μM。