海洋无脊椎动物共生微生物的生物和化学多样性。
Biological and Chemical Diversity of Ascidian-Associated Microorganisms.
机构信息
Department of Bioengineering, School of Marine Science and Technology, Harbin Institute of Technology, Weihai 264209, China.
Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
出版信息
Mar Drugs. 2018 Oct 1;16(10):362. doi: 10.3390/md16100362.
Ascidians are a class of sessile filter-feeding invertebrates, that provide unique and fertile niches harboring various microorganisms, such as bacteria, actinobacteria, cyanobacteria and fungi. Over 1000 natural products, including alkaloids, cyclic peptides, and polyketides, have been isolated from them, which display diverse properties, such as antibacterial, antifungal, antitumor, and anti-inflammatory activities. Strikingly, direct evidence has confirmed that ~8% of natural products from ascidians are actually produced by symbiotic microorganisms. In this review, we present 150 natural products from microorganisms associated with ascidians that have been reported up to 2017.
海鞘是一类固着滤食无脊椎动物，它们提供了独特而肥沃的小生境，栖息着各种微生物，如细菌、放线菌、蓝细菌和真菌。从它们中已经分离出超过 1000 种天然产物，包括生物碱、环肽和聚酮化合物，这些天然产物具有多种特性，如抗菌、抗真菌、抗肿瘤和抗炎活性。引人注目的是，直接证据已经证实，海鞘中约 8%的天然产物实际上是由共生微生物产生的。在这篇综述中，我们介绍了截至 2017 年报道的与海鞘相关的微生物产生的 150 种天然产物。
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