Ren J, Xu Y F, Kuang T H, Chen J, Liu Y X
Department of Oncology, Hangzhou Third People's Hospital, Hangzhou 310009, China.
Zhonghua Zhong Liu Za Zhi. 2017 Apr 23;39(4):263-268. doi: 10.3760/cma.j.issn.0253-3766.2017.04.005.
To investigate the prognosis of osteosarcoma patients with lung metastases and its correlated factors. The clinical data of 104 osteosarcoma patients with lung metastasis from April 2007 to September 2015 were retrospectively analyzed. Univariate analysis was performed using Kaplan-Meier and Log rank test. Multivariate Cox regression was applied to analyze independent prognostic factor for patient survival. The one-year, two-year and five-year survival rates of the 104 osteosarcoma patients with lung pulmonary metastasis were 93.3%, 61.5% and 11.5%, respectively, and the median survival time was 33 months. The univariate analysis revealed that number of lung metastases, objective response of first-line chemotherapy and therapeutic methods for lung metastases were significant prognostic factors for patient survival, whereas gender, age, time to lung metastasis and time to other metastasis were not (>0.05). The multivariate analysis indicated that number of lung metastases, objective response of first-line chemotherapy and therapeutic methods for lung metastases were independent significant prognostic factors for patient survival. The prognosis of osteosarcoma patients with advanced lung metastases and active treatment is better. Surgery and adjuvant chemotherapy could effectively prolong survival time for osteosarcoma patients with pulmonary metastasis.
探讨骨肉瘤肺转移患者的预后及其相关因素。回顾性分析2007年4月至2015年9月期间104例骨肉瘤肺转移患者的临床资料。采用Kaplan-Meier法和Log rank检验进行单因素分析。应用多因素Cox回归分析患者生存的独立预后因素。104例骨肉瘤肺转移患者的1年、2年和5年生存率分别为93.3%、61.5%和11.5%，中位生存时间为33个月。单因素分析显示，肺转移灶数量、一线化疗客观反应及肺转移治疗方法是患者生存的重要预后因素，而性别、年龄、发生肺转移时间及发生其他转移时间则不是（>0.05）。多因素分析表明，肺转移灶数量、一线化疗客观反应及肺转移治疗方法是患者生存的独立重要预后因素。晚期肺转移且积极治疗的骨肉瘤患者预后较好。手术及辅助化疗可有效延长骨肉瘤肺转移患者的生存时间。
