Yu Yunjiang, Li Liangzhong, Li Hongyan, Yu Xiaowei, Zhang Yanping, Wang Qiong, Zhou Zhixiang, Gao Dandan, Ye Hao, Lin Bigui, Ma Ruixue
State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, Center for Environmental Health Research, South China Institute of Environmental Sciences, MEP, Guangzhou 510535, China.
State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, Center for Environmental Health Research, South China Institute of Environmental Sciences, MEP, Guangzhou 510535, China.
Environ Pollut. 2017 Sep;228:305-310. doi: 10.1016/j.envpol.2017.05.008. Epub 2017 May 25.
Individuals are exposed to brominated flame retardants (BFRs), including tetrabromobisphenol A (TBBPA), on a daily basis because of their widespread usage. These compounds may have adverse effects on human health. In the present study, dermal absorption experiments were conducted in vivo to predict the adhesion, penetration, and bioavailability of TBBPA. TBBPA was administered to Wistar rats for 6 h by repeated dermal exposure at doses of 20, 60, 200, and 600 mg of TBBPA per kg of body weight (bw). The skin adhesion coefficient (AC) was calculated using a difference-value method and ranged from 0.12 to 3.25 mg/cm and 0.1 to 2.56 mg/cm for the male and female rats, respectively. The adhesion rate was 70.92%. According to Fick's first law of diffusion, the diffusion constant (D) was 1.4 × 10 cm/h and the permeation coefficient (K) was 1.26 × 10 cm/h for TBBPA. TBBPA levels in the blood, urine, and feces of the male rats were significantly higher than those in the female rats. The dermal bioavailability of TBBPA was 24.71% for male rats and 20.05% for female rats 24 h after exposure.
由于溴化阻燃剂（BFRs）的广泛使用，人们每天都会接触到包括四溴双酚A（TBBPA）在内的这些物质。这些化合物可能会对人体健康产生不利影响。在本研究中，进行了体内皮肤吸收实验，以预测TBBPA的黏附、渗透和生物利用度。通过以每千克体重（bw）20、60、200和600毫克TBBPA的剂量对Wistar大鼠进行重复皮肤暴露6小时来给予TBBPA。使用差值法计算皮肤黏附系数（AC），雄性和雌性大鼠的AC分别为0.12至3.25毫克/平方厘米和0.1至2.56毫克/平方厘米。黏附率为70.92%。根据菲克第一扩散定律，TBBPA的扩散常数（D）为1.4×10厘米/小时，渗透系数（K）为1.26×10厘米/小时。雄性大鼠血液、尿液和粪便中的TBBPA水平显著高于雌性大鼠。暴露24小时后，雄性大鼠TBBPA的皮肤生物利用度为24.71%，雌性大鼠为20.05%。
