State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, Center for Environmental Health Research, Ministry of Ecology and Environment, Guangzhou 510535, China.
State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, Center for Environmental Health Research, Ministry of Ecology and Environment, Guangzhou 510535, China.
Environ Pollut. 2020 Aug;263(Pt B):114440. doi: 10.1016/j.envpol.2020.114440. Epub 2020 Mar 26.
Tetrabromobisphenol-A (TBBPA) is an emerging organic pollutant and a commonly used brominated flame retardant that has received much attention owing to its toxicity. Although TBBPA is ubiquitously detected in atmospheric particulate matter and dust, few studies have investigated the sub-chronic inhalation exposure to TBBPA. To further understand the excretion characteristics and tissue accumulation of TBBPA after inhalation exposure, we used the rat model to conduct a sub-chronic inhalation exposure study. Male rats were administered with different doses of aerosol TBBPA (12.9, 54.6, 121.6, and 455.0 mg/m). TBBPA was found in the excretion (feces and urine) and all the target tissues (lung, liver, heart, thymus gland, spleen, testicles, muscles, kidneys, brain and serum). Feces were the main route of excretion, which contributed 19.18% to 72.54% (urine <0.10%). TBBPA excretion through feces following inhalation administration was much higher than that following oral and dermal exposure, thereby indicating lower bioavailability of TBBPA under inhalation exposure. Liver and serum showed higher levels of TBBPA compared with those of other tissues, thereby suggesting tissue-specific accumulation of TBBPA in rats. Owing to the relative non-invasiveness of serum sampling and greatest TBBPA concentration among the tissues, serum is a suitable matrix for estimation of TBBPA bioaccumulation after inhalation exposure.
四溴双酚 A（TBBPA）是一种新兴的有机污染物，也是一种常用的溴化阻燃剂，由于其毒性而备受关注。尽管 TBBPA 广泛存在于大气颗粒物和灰尘中，但很少有研究调查过亚慢性吸入 TBBPA 暴露。为了进一步了解吸入暴露后 TBBPA 的排泄特征和组织积累，我们使用大鼠模型进行了亚慢性吸入暴露研究。雄性大鼠给予不同剂量的气溶胶 TBBPA（12.9、54.6、121.6 和 455.0mg/m3）。TBBPA 存在于排泄物（粪便和尿液）和所有靶组织（肺、肝、心、胸腺、脾、睾丸、肌肉、肾脏、脑和血清）中。粪便是主要的排泄途径，占 19.18%至 72.54%（尿液<0.10%）。与口服和皮肤暴露相比，吸入给药后 TBBPA 通过粪便的排泄要高得多，这表明在吸入暴露下 TBBPA 的生物利用度较低。肝脏和血清中的 TBBPA 水平高于其他组织，表明 TBBPA 在大鼠中有组织特异性积累。由于血清采样相对无创且在组织中 TBBPA 浓度最大，因此血清是估计吸入暴露后 TBBPA 生物积累的合适基质。
