Sledzińska Marta, Szlagatys-Sidorkiewicz Agnieszka, Brzezinski Michał, Kaźmierska Katarzyna, Sledziński Tomasz, Kamińska Barbara
Department of Pediatrics, Gastroenterology, Hepatology and Nutrition, Medical University of Gdansk, Gdansk, Poland.
Department of Pediatrics, Gastroenterology, Hepatology and Nutrition, Medical University of Gdansk, Gdansk, Poland.
Adv Med Sci. 2017 Sep;62(2):383-386. doi: 10.1016/j.advms.2017.04.002. Epub 2017 May 25.
The aim of this study was to verify if serum chemerin in children correlates with body weight, fat mass, selected inflammatory markers, parameters of liver function, lipid and glucose metabolism.
The study included children aged 5-17 years with normal body weight (<85th BMI percentile, n=43) or overweight (≥85th BMI percentile, n=58). Serum concentrations of chemerin were determined with ELISA.
Children with excess body weight presented with significantly higher serum concentrations of chemerin. Serum chemerin correlated positively with body weight, absolute BMI and its percentile, fat mass, systolic blood pressure, CRP, ALT, insulin and HOMA-IR.
Serum level of chemerin may serve as a measure of ongoing obesity-related inflammation, early marker of subclinical liver dysfunction and metabolic syndrome in overweight pediatric patients.
本研究旨在验证儿童血清chemerin是否与体重、脂肪量、选定的炎症标志物、肝功能指标、脂质和葡萄糖代谢相关。
本研究纳入了5至17岁体重正常（BMI百分位数<85，n = 43）或超重（BMI百分位数≥85，n = 58）的儿童。采用酶联免疫吸附测定法（ELISA）测定血清chemerin浓度。
超重儿童的血清chemerin浓度显著更高。血清chemerin与体重、绝对BMI及其百分位数、脂肪量、收缩压、CRP、ALT、胰岛素和HOMA-IR呈正相关。
血清chemerin水平可作为超重儿科患者肥胖相关炎症持续存在的指标、亚临床肝功能障碍和代谢综合征的早期标志物。
