组织因子表达不能预测乳腺癌患者的死亡率。
Tissue Factor Expression Does Not Predict Mortality in Breast Cancer Patients.
作者信息
Stämpfli Simon F, Akhmedov Alexander, Hausladen Silke, Varga Zsuzsanna, Dedes Konstantin J, Hellermann Jens, Lüscher Thomas F, Kristiansen Glen, Tanner Felix C, Breitenstein Alexander
机构信息
Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.
Department of Cardiology, University Heart Center Zurich, Zurich, Switzerland.
出版信息
Anticancer Res. 2017 Jun;37(6):3259-3264. doi: 10.21873/anticanres.11689.
BACKGROUND
Tissue factor (TF), the trigger of coagulation, not only initiates thrombus formation, but also elicits tumor growth and invasion in breast cancer. However, the characterization of TF expression in breast cancer tissue and its prognostic value remain unclear.
MATERIALS AND METHODS
Three hundred and three primary breast cancer specimens from the local tumor tissue database were immunostained for TF expression and evaluated semiquantitatively. Tumor characteristics (size, grade, nodal status, and ER expression) as well as patient's survival were assessed.
RESULTS
Expression of TF was detected in 99% of specimens with higher expression in invasive lobular than ductal carcinoma (p=0.008). TF expression correlated with ER expression (p<0.0001) and inversely with tumor grade (p=0.006). Survival analysis did not reveal any prognostic impact of TF expression (p=0.966).
CONCLUSION
This study - by analyzing TF expression in the largest cohort of breast cancer patients so far - does not support a prognostic impact of TF expression.
背景
组织因子（TF）作为凝血的触发因子，不仅启动血栓形成，还在乳腺癌中引发肿瘤生长和侵袭。然而，TF在乳腺癌组织中的表达特征及其预后价值仍不明确。
材料与方法
对来自当地肿瘤组织数据库的303例原发性乳腺癌标本进行TF表达免疫染色，并进行半定量评估。评估肿瘤特征（大小、分级、淋巴结状态和雌激素受体表达）以及患者生存率。
结果
99%的标本检测到TF表达，小叶浸润癌中的表达高于导管癌（p=0.008）。TF表达与雌激素受体表达相关（p<0.0001），与肿瘤分级呈负相关（p=0.006）。生存分析未显示TF表达有任何预后影响（p=0.966）。
结论
本研究通过分析迄今为止最大队列乳腺癌患者的TF表达，不支持TF表达具有预后影响。
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