线粒体miRNA维持心脏跳动。

MitomiRs Keep the Heart Beating.

作者信息

Das Samarjit, Vasanthi Hannah R, Parjapath Ramesh

机构信息

Department of Pathology, Cardiovascular Division, Johns Hopkins University, Baltimore, MD, 21205, USA.

Department of Biotechnology, Pondicherry University, Puducherry, India.

出版信息

Adv Exp Med Biol. 2017;982:431-450. doi: 10.1007/978-3-319-55330-6_23.

DOI:10.1007/978-3-319-55330-6_23

PMID:28551801

Abstract

In this chapter, we focus on the microRNAs (miRNAs or miRs) that have been found in the mitochondrial compartment, and target either mitochondrial or nuclear encoded genes present in mitochondria, leading to an alteration of mitochondrial function. We term this subset of miRNAs as "MitomiRs".

摘要

在本章中，我们聚焦于已在线粒体区室中发现的微小RNA（miRNA或miR），它们靶向线粒体中存在的线粒体编码基因或核编码基因，从而导致线粒体功能改变。我们将这一微小RNA子集称为“线粒体微小RNA（MitomiR）”。