Rappoport Daniel, Leiba Hana
Department of Ophthalmology, Kaplan Medical Center, Rehovot.
The Faculty of Medicine, the Hebrew University, Jerusalem.
Harefuah. 2017 Feb;156(2):71-73.
Bisphosphonates are a group of drugs used for treatment in several bone diseases such as osteoporosis in women, Paget's disease, hypercalcemia of malignancy, primary malignancies of the bone and metastatic bone disease (breast and prostate carcinoma). Numerous reports in the medical literature described ocular side effects in patients treated with these drugs. We report on two patients, treated with bisphosphonates due to malignancy, who presented with unilateral and bilateral uveitis. Treatment of the ocular inflammation should include local and systemic treatment and stopping the systemic use of bisphosphonates. Another alternative is switching to another bisphosphonate with less ocular side effects.
