AlRahabi Mothanna K, Ghabbani Hani M
College of Dentistry, Taibah University, Madinah Al Munawwarah, Kingdom of Saudi Arabia. E-mail.
Saudi Med J. 2018 Mar;39(3):232-238. doi: 10.15537/smj.2018.3.20923.
Bisphosphonates are stable structural analogs of pyrophosphate, which suppress the activity of osteoclasts, leading to decreased bone resorption. They are essential medications in the treatment of osteoporosis. Osteonecrosis of the jaw is a serious adverse effect of bisphosphonate therapy. The prevalence of bisphosphonate-related osteonecrosis of the jaw varies from 0% to 28%, and it can be triggered by dental extraction and trauma. Root canal therapy can delay, or even eliminate, the need for tooth extraction, and therefore, may reduce the risk of bisphosphonate-related osteonecrosis of the jaw. We suggest that this might be the best treatment for teeth with pulpal and/or periapical disease.
双膦酸盐是焦磷酸盐的稳定结构类似物，可抑制破骨细胞的活性，从而减少骨吸收。它们是治疗骨质疏松症的重要药物。颌骨坏死是双膦酸盐治疗的一种严重不良反应。双膦酸盐相关颌骨坏死的发生率在0%至28%之间，可由拔牙和创伤引发。根管治疗可以延迟甚至消除拔牙的必要性，因此可能降低双膦酸盐相关颌骨坏死的风险。我们认为这可能是治疗牙髓和/或根尖周疾病牙齿的最佳方法。
