Ryuno Hiroki, Naguro Isao, Kamiyama Miki
Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Adv Biol Regul. 2017 Dec;66:72-84. doi: 10.1016/j.jbior.2017.05.003. Epub 2017 May 20.
Cancer is a major problem in public health and is one of the leading causes of mortality worldwide. Many types of cancer cells exhibit aberrant cellular signal transduction in response to stress, which often leads to oncogenesis. Mitogen-activated protein kinase (MAPK) signal cascades are one of the important intracellular stress signaling pathways closely related to cancer. The key molecules in MAPK signal cascades that respond to various types of stressors are apoptosis signal-regulating kinase (ASK) family members; ASK1, ASK2 and ASK3. ASK family members are activated by a wide variety of stressors, and they regulate various cellular responses, such as cell proliferation, inflammation and apoptosis. In this review, we will discuss both the oncogenic and anti-oncogenic roles of the ASK family members in various contexts of cancer development with deeper insights into the involvement of ASK family members in cancer pathology.
癌症是公共卫生领域的一个重大问题，也是全球主要的死亡原因之一。许多类型的癌细胞在应激反应中表现出异常的细胞信号转导，这往往导致肿瘤发生。丝裂原活化蛋白激酶（MAPK）信号级联是与癌症密切相关的重要细胞内应激信号通路之一。MAPK信号级联中响应各种应激源的关键分子是凋亡信号调节激酶（ASK）家族成员，即ASK1、ASK2和ASK3。ASK家族成员可被多种应激源激活，并调节各种细胞反应，如细胞增殖、炎症和凋亡。在本综述中，我们将探讨ASK家族成员在癌症发展的各种情况下的致癌和抗癌作用，并更深入地了解ASK家族成员在癌症病理学中的作用。
