Nishida Takuto, Hattori Kazuki, Watanabe Kengo
Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan.
Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan.
Adv Biol Regul. 2017 Dec;66:2-22. doi: 10.1016/j.jbior.2017.05.004. Epub 2017 May 22.
Apoptosis signal-regulating kinase 1 (ASK1) was identified as a MAP3K that activates the JNK and p38 pathways, and subsequent studies have reported ASK2 and ASK3 as members of the ASK family. The ASK family is activated by various intrinsic and extrinsic stresses, including oxidative stress, ER stress and osmotic stress. Numerous lines of evidence have revealed that members of the ASK family are critical for signal transduction systems to control a wide range of stress responses such as cell death, differentiation and cytokine induction. In this review, we focus on the precise signaling mechanisms of the ASK family in response to diverse stressors.
凋亡信号调节激酶1（ASK1）被鉴定为一种激活JNK和p38信号通路的丝裂原活化蛋白激酶激酶激酶（MAP3K），随后的研究报道ASK2和ASK3是ASK家族的成员。ASK家族可被多种内在和外在应激激活，包括氧化应激、内质网应激和渗透压应激。大量证据表明，ASK家族成员对于信号转导系统控制广泛的应激反应（如细胞死亡、分化和细胞因子诱导）至关重要。在本综述中，我们重点关注ASK家族响应不同应激源的精确信号传导机制。
