CÚRAM, Centre for Research in Medical Devices, National University of Ireland Galway, Ireland.
CÚRAM, Centre for Research in Medical Devices, National University of Ireland Galway, Ireland; Department of Mining-Metallurgy Engineering and Materials Science & POLYMAT, University of the Basque Country, Bilbao, Spain.
Nanomedicine. 2018 Oct;14(7):2397-2405. doi: 10.1016/j.nano.2017.03.022. Epub 2017 May 26.
Excess reactive oxygen species (ROS) has been implicated in numerous diseases including cancer, cardiovascular and neurodegenerative diseases. Overexpression of ROS can lead to oxidative stress and subsequently to HO-mediated cell apoptosis. In this study, it was demonstrated that biodegradable PLGA microspheres coated with collagen type I and decorated with MnO nanoparticles acted as ROS scavengers controlling the HO-mediated apoptosis of cells undergoing oxidative stress. The results showed that the functionalized collagen spheres can protect cells even under very harsh conditions of oxidative stress.
过量的活性氧（ROS）与包括癌症、心血管和神经退行性疾病在内的多种疾病有关。ROS 的过度表达会导致氧化应激，进而导致 HO 介导的细胞凋亡。在这项研究中，已经证明，用胶原蛋白 I 包被并装饰有 MnO 纳米粒子的可生物降解的 PLGA 微球作为 ROS 清除剂，可以控制发生氧化应激的细胞中由 HO 介导的细胞凋亡。结果表明，即使在非常恶劣的氧化应激条件下，功能化胶原球也可以保护细胞。
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