National Nanotechnology Research Center (UNAM), Bilkent University, Ankara, Turkey.
National Nanotechnology Research Center (UNAM), Bilkent University, Ankara, Turkey; Neuroscience Program, Bilkent University, Ankara, Turkey.
Nanomedicine. 2018 Oct;14(7):2433-2454. doi: 10.1016/j.nano.2017.03.021. Epub 2017 May 26.
One-dimensional (1D) carbon nanotubes (CNTs) and the two-dimensional (2D) graphene represent the most widely studied allotropes of carbon. Due to their unique structural, electrical, mechanical and optical properties, 1D and 2D carbon nanostructures are considered to be leading candidates for numerous applications in biomedical fields, including tissue engineering, drug delivery, bioimaging and biosensors. The biocompatibility and toxicity issues associated with these nanostructures have been a critical impediment for their use in biomedical applications. In this review, we present an overview of the various materials types, properties, functionalization strategies and characterization methods of 1D and 2D carbon nanomaterials and their derivatives in terms of their biomedical applications. In addition, we discuss various factors and mechanisms affecting their toxicity and biocompatibility.
一维（1D）碳纳米管（CNTs）和二维（2D）石墨烯代表了最广泛研究的碳同素异形体。由于其独特的结构、电学、机械和光学性能，一维和二维碳纳米结构被认为是在生物医学领域的众多应用中的首选候选材料，包括组织工程、药物输送、生物成像和生物传感器。与这些纳米结构相关的生物相容性和毒性问题一直是它们在生物医学应用中的关键障碍。在这篇综述中，我们介绍了一维和二维碳纳米材料及其衍生物的各种材料类型、性质、功能化策略和表征方法，以及它们在生物医学应用中的情况。此外，我们还讨论了影响其毒性和生物相容性的各种因素和机制。
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