Amity Institute of Applied Sciences, Amity University, Sector-125, Noida 201313, India.
School of Mechanical Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar 752050, India.
Curr Med Chem. 2019;26(38):6851-6877. doi: 10.2174/0929867326666181126113605.
The unique mechanical, electrical, thermal, chemical and optical properties of carbon based nanomaterials (CBNs) like: Fullerenes, Graphene, Carbon nanotubes, and their derivatives made them widely used materials for various applications including biomedicine. Few recent applications of the CBNs in biomedicine include: cancer therapy, targeted drug delivery, bio-sensing, cell and tissue imaging and regenerative medicine. However, functionalization renders the toxicity of CBNs and makes them soluble in several solvents including water, which is required for biomedical applications. Hence, this review represents the complete study of development in nanomaterials of carbon for biomedical uses. Especially, CBNs as the vehicles for delivering the drug in carbon nanomaterials is described in particular. The computational modeling approaches of various CBNs are also addressed. Furthermore, prospectus, issues and possible challenges of this rapidly developing field are highlighted.
碳基纳米材料(CBNs)具有独特的机械、电气、热、化学和光学特性,如富勒烯、石墨烯、碳纳米管及其衍生物,使它们广泛应用于各种领域,包括生物医药。CBNs 在生物医药领域的一些近期应用包括癌症治疗、靶向药物输送、生物传感、细胞和组织成像以及再生医学。然而,功能化会改变 CBNs 的毒性,并使它们在包括水在内的几种溶剂中溶解,这是生物医药应用所必需的。因此,本综述代表了碳基纳米材料在生物医药应用方面的全面研究进展。特别是,特别描述了 CBNs 作为碳纳米材料中药物输送载体的作用。还解决了各种 CBNs 的计算建模方法。此外,还强调了这个快速发展领域的前景、问题和可能的挑战。