Takeshita Jun, Kobayashi Hiromitsu, Shimoe Yutaka, Sone Jun, Sobue Gen, Kuriyama Masaru
Department of Neurology, Brain Attack Center Ota Memorial Hospital.
Department of Radiology, Brain Attack Center Ota Memorial Hospital.
Rinsho Shinkeigaku. 2017 Jun 28;57(6):303-306. doi: 10.5692/clinicalneurol.cn-000994. Epub 2017 May 26.
A 65-year-old man had a transient amnesia for about 3 hours. Similar symptoms appeared three years ago. He did not manifest dementia, cerebellar ataxia and involuntary movements. Peripheral neuropathy was observed by the neurophysiological examinations. Diffusion weighted image showed high intensity signal in the area of the corticomedullary junction of the frontal to parietal lobes and immunohistochemical studies of biopsied skin revealed many intranuclear inclusion bodies. Adult-onset neuronal intranuclear inclusion disease was diagnosed. As there was no similar member in his family, he was a sporadic case. Clinical characteristics of his amnesia was fulfilled with the criteria of transient global amnesia (TGA). The transient disturbance of limbic system was suspected.
一名65岁男性出现了约3小时的短暂性失忆。类似症状三年前也曾出现。他未表现出痴呆、小脑共济失调和不自主运动。神经生理学检查发现了周围神经病变。弥散加权成像显示额顶叶皮质髓质交界区有高强度信号，活检皮肤的免疫组织化学研究发现许多核内包涵体。诊断为成人型神经元核内包涵体病。由于其家族中没有类似病例，他属于散发病例。其失忆的临床特征符合短暂性全面性失忆（TGA）的标准。怀疑存在边缘系统的短暂性紊乱。
