Katsoulis S, Conlon J M
Clinical Research Group, Max-Planck-Gesellschaft, University of Göttingen, F.R.G.
Eur J Pharmacol. 1988 Dec 13;158(3):251-6. doi: 10.1016/0014-2999(88)90074-x.
Neurotensin, xenopsin and neuromedin N had a biphasic effect (initial small relaxation followed by a sustained contraction) on the motility of longitudinal muscle strips from the guinea pig gastric corpus. Kinetensin was without effect. Tetrodotoxin, adrenaline, histamine, 5-hydroxytryptamine, opioid peptides, angiotensin II and antagonists of acetylcholine, and desensitization of the strips to bradykinin did not modify the action of neurotensin. The contraction phase was inhibited in a concentration-dependent manner by indomethacin and acetylsalicylate, demonstrating that this activity of neurotensin was dependent on prostaglandin synthesis. The preparation responded to exogenous prostaglandins E1, E2, F1 alpha and F2 alpha with concentration-dependent contractions. The relaxation phase was abolished by verapamil and apamin, indicating the presence of inhibitory neurotensin receptors on smooth muscle cells that are linked to ionic channels.
神经降压素、异速激肽和神经介素N对豚鼠胃体纵行肌条的运动具有双相作用（最初是轻微舒张，随后是持续性收缩）。激肽释放酶原无作用。河豚毒素、肾上腺素、组胺、5-羟色胺、阿片肽、血管紧张素II、乙酰胆碱拮抗剂以及肌条对缓激肽的脱敏作用均未改变神经降压素的作用。消炎痛和乙酰水杨酸以浓度依赖的方式抑制收缩期，表明神经降压素的这种活性依赖于前列腺素的合成。该制剂对外源性前列腺素E1、E2、F1α和F2α产生浓度依赖性收缩反应。维拉帕米和蜂毒明肽消除了舒张期，表明平滑肌细胞上存在与离子通道相关的抑制性神经降压素受体。
