神经降压素相关肽对豚鼠食管运动的影响。

Effects of neurotensin-related peptides on the motility of the guinea pig oesophagus.

作者信息

Katsoulis S, Conlon J M

机构信息

Clinical Research Group for Gastrointestinal Endocrinology, Max-Planck-Gesellschaft, University of Göttingen, F.R.G.

出版信息

Eur J Pharmacol. 1988 Aug 2;152(3):363-6. doi: 10.1016/0014-2999(88)90733-9.

DOI:10.1016/0014-2999(88)90733-9

PMID:2906006

Abstract

Neurotensin, neuromedin N and xenopsin induced a monophasic and concentration-dependent contraction of the intact guinea pig oesophagus but kinetensin was without effect. The responses were completely abolished by tetrodotoxin and atropine but were unaffected by hexamethonium. The maximum response induced by neurotensin was reduced (20-30%) by somatostatin and by dynorphin-(1-13) in a naloxone-reversible manner. Neurotensin did not contract the isolated muscularis mucosae. The effects of neurotensin-related peptides on the motility of the oesophagus are mediated exclusively through the release of acetylcholine.

摘要

神经降压素、神经介素N和爪蟾肽可诱导完整豚鼠食管出现单相且浓度依赖性收缩，但激肽释放酶原无此作用。河豚毒素和阿托品可完全消除这些反应，但六甲铵对此无影响。神经降压素诱导的最大反应可被生长抑素和强啡肽-（1-13）以纳洛酮可逆的方式降低（20%-30%）。神经降压素不会使分离的黏膜肌层收缩。神经降压素相关肽对食管运动的影响完全是通过乙酰胆碱的释放介导的。