Kline Mark A, Wei Xiaoxi, Horner Ian J, Liu Rui, Chen Shuang, Chen Si, Yung Ka Yi, Yamato Kazuhiro, Cai Zhonghou, Bright Frank V, Zeng Xiao Cheng, Gong Bing
Department of Chemistry , the State University of New York at Buffalo , Buffalo , New York , USA 14260 . Email:
Department of Chemistry , University of Nebraska-Lincoln , Lincoln , Nebraska 68588 , USA.
Chem Sci. 2015 Jan 1;6(1):152-157. doi: 10.1039/c4sc02380c. Epub 2014 Sep 16.
As the third-generation rigid macrocycles evolved from progenitor , cyclic aromatic oligoamides , with a backbone of reduced constraint, exhibit extremely strong stacking with an astoundingly high affinity (estimated lower limit of > 10 M in CHCl), which leads to dispersed tubular stacks that undergo further assembly in solution. Computational study reveals a very large binding energy (-49.77 kcal mol) and indicates highly cooperative local dipole interactions that account for the observed strength and directionality for the stacking of . In the solid-state, X-ray diffraction (XRD) confirms that the aggregation of results in well-aligned tubular stacks. The persistent tubular assemblies of , with their non-deformable sub-nm pore, are expected to possess many interesting functions. One such function, transmembrane ion transport, is observed for .
作为从母体环状芳香族低聚酰胺进化而来的第三代刚性大环化合物，其主链约束性降低，表现出极强的堆积作用，具有惊人的高亲和力（在CHCl中估计下限>10 M），这导致形成分散的管状堆积物，在溶液中会进一步组装。计算研究揭示了非常大的结合能（-49.77 kcal/mol），并表明存在高度协同的局部偶极相互作用，这解释了所观察到的[具体物质]堆积的强度和方向性。在固态下，X射线衍射（XRD）证实[具体物质]的聚集导致形成排列良好的管状堆积物。[具体物质]持久的管状组装体具有不可变形的亚纳米级孔隙，预计具有许多有趣的功能。其中一种功能，即跨膜离子运输，已在[具体物质]中观察到。
