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血管闭塞性镰状细胞危象背景下的胰腺炎:罕见病例

Pancreatitis in the Setting of Vaso-occlusive Sickle Cell Crisis: A Rare Encounter.

作者信息

Hasan Badar, Asif Talal, Braun Cody, Bahaj Waled, Dosokey Eslam, Pauly Rebecca R

机构信息

Department of Internal Medicine, University of Missouri Kansas City (UMKC).

出版信息

Cureus. 2017 Apr 25;9(4):e1193. doi: 10.7759/cureus.1193.

DOI:10.7759/cureus.1193
PMID:28553571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5444912/
Abstract

Acute pancreatitis is a common cause of acute abdominal pain. Gallstones and alcohol abuse account for the majority of the cases. Pancreatic ischemia is an uncommon but established cause of pancreatitis associated with connective tissue diseases, vasculitis, and shock. Our case highlights a rare case of vaso-occlusive crisis (VOC) in a patient with sickle cell (SC) disease leading to pancreatitis. Treatment remains largely conservative but exchange transfusion may be the therapy of choice in severely hypoxic patients or in patients with high pre-treatment hemoglobin S levels.

摘要

急性胰腺炎是急性腹痛的常见病因。胆结石和酗酒是大多数病例的病因。胰腺缺血是与结缔组织病、血管炎和休克相关的胰腺炎的一种罕见但已明确的病因。我们的病例突出了1例镰状细胞(SC)病患者发生血管闭塞性危象(VOC)导致胰腺炎的罕见病例。治疗主要仍为保守治疗,但对于严重缺氧患者或治疗前血红蛋白S水平高的患者,换血疗法可能是首选治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0862/5444912/567f3ae6cada/cureus-0009-00000001193-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0862/5444912/29b30893f731/cureus-0009-00000001193-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0862/5444912/567f3ae6cada/cureus-0009-00000001193-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0862/5444912/29b30893f731/cureus-0009-00000001193-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0862/5444912/567f3ae6cada/cureus-0009-00000001193-i02.jpg

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Abdom Radiol (NY). 2025 Jun 30. doi: 10.1007/s00261-025-05083-8.
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本文引用的文献

1
The epidemiology of pancreatitis and pancreatic cancer.胰腺炎和胰腺癌的流行病学。
Gastroenterology. 2013 Jun;144(6):1252-61. doi: 10.1053/j.gastro.2013.01.068.
2
Gastrointestinal and hepatic complications of sickle cell disease.镰状细胞病的胃肠道和肝脏并发症。
Clin Gastroenterol Hepatol. 2010 Jun;8(6):483-9; quiz e70. doi: 10.1016/j.cgh.2010.02.016. Epub 2010 Mar 6.
3
Images of interest. Gastrointestinal: ischemic enteritis and sickle cell disease.感兴趣的影像。胃肠道:缺血性肠炎和镰状细胞病。
J Gastroenterol Hepatol. 2004 Nov;19(11):1318. doi: 10.1111/j.1440-1746.2004.03630.x.
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Acute Chest Syndrome: the role of erythro-exchange in patients with sickle cell disease in Sicily.急性胸部综合征:红细胞置换在西西里岛镰状细胞病患者中的作用
Transfus Apher Sci. 2003 Aug;29(1):39-44. doi: 10.1016/s1473-0502(03)00096-x.
5
Acute pancreatitis during sickle cell vaso-occlusive painful crisis.镰状细胞血管闭塞性疼痛危象期间的急性胰腺炎
Am J Hematol. 2003 Jul;73(3):190-3. doi: 10.1002/ajh.10344.