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癌症之于胚胎学犹如突变之于遗传学:癌症作为胚胎学现象的假说。

Cancer Is to Embryology as Mutation Is to Genetics: Hypothesis of the Cancer as Embryological Phenomenon.

作者信息

Cofre Jaime, Abdelhay Eliana

机构信息

Laboratório de Embriologia Molecular e Câncer, Universidade Federal de Santa Catarina, Sala 313b, 88040-900 Florianópolis, SC, Brazil.

Divisão de Laboratórios do CEMO, Instituto Nacional do Câncer, Rio de Janeiro, RJ, Brazil.

出版信息

ScientificWorldJournal. 2017;2017:3578090. doi: 10.1155/2017/3578090. Epub 2017 May 3.

Abstract

Despite numerous advances in cell biology, genetics, and developmental biology, cancer origin has been attributed to genetic mechanisms primarily involving mutations. Embryologists have expressed timidly cancer embryological origin with little success in leveraging the discussion that cancer could involve a set of conventional cellular processes used to build the embryo during morphogenesis. Thus, this "cancer process" allows the harmonious and coherent construction of the embryo structural base, and its implementation as the embryonic process involves joint regulation of differentiation, proliferation, cell invasion, and migration, enabling the human being recreation of every generation. On the other hand, "cancer disease" is the representation of an abnormal state of the cell that might happen in the stem cells of an adult person, in which the mechanism for joint gene regulating of differentiation, proliferation, cell invasion, and migration could be reactivated in an entirely inappropriate context.

摘要

尽管细胞生物学、遗传学和发育生物学取得了诸多进展,但癌症起源主要归因于主要涉及突变的遗传机制。胚胎学家曾谨慎地表达过癌症的胚胎学起源,但在推动关于癌症可能涉及一组用于在形态发生过程中构建胚胎的传统细胞过程的讨论方面收效甚微。因此,这种“癌症过程”允许胚胎结构基础的和谐与连贯构建,而其作为胚胎过程的实施涉及分化、增殖、细胞侵袭和迁移的联合调节,从而实现每一代人类的再生。另一方面,“癌症疾病”是细胞异常状态的表现,这种异常可能发生在成年人的干细胞中,其中分化、增殖、细胞侵袭和迁移的联合基因调节机制可能在完全不适当的背景下被重新激活。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a54/5434308/32b154d05da3/TSWJ2017-3578090.001.jpg

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