Li Yanli, Shi Juan, Huang Xiaolin, Wang Rui, Gu Bin, Liang Peiwen, Zhao Shaoqian, Sun Yingkai, Liu Wen, Deng Yuying, Xi Liuqing, Zhao Dandan, Song Dalong, Cao Yanan, Zhang Yifei, Gu Weiqiong, Hong Jie
Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China (mainland).
Med Sci Monit. 2017 May 29;23:2612-2618. doi: 10.12659/msm.902450.
BACKGROUND The aim of this study was to explore the association between glycated hemoglobin (HbA1c) level and albuminuria in young nondiabetic people with obesity. MATERIAL AND METHODS A total of 537 young nondiabetic people with obesity were enrolled in this cross-sectional study, which was approved by the Rui-jin Hospital Ethics Committee. Albuminuria was defined as a urinary albumin-to-creatinine ratio (ACR) ≥30 mg/g. Multivariate logistic regression was used to analyze the association between HbA1c level and albuminuria. RESULTS Urinary ACR progressively increased across the tertiles of HbA1c level (P for trend <0.05). HbA1c levels were positively associated with the risk of albuminuria in the logistic regression analysis after adjustment for confounding factors. The adjusted odds ratio (OR) for albuminuria was 3.72 (95% confidence interval [CI], 1.25-11.00; P=0.017) when comparing between the highest (≥5.7%) and lowest tertiles of HbA1c level (≤5.3%). Moreover, an increment of 1 SD in HbA1c level increased the risk of albuminuria in a fully adjusted model (OR, 1.73; 95% CI, 1.25-2.46). CONCLUSIONS These data suggest that HbA1c level was independently associated with albuminuria in young nondiabetic people with obesity.
背景 本研究旨在探讨肥胖的非糖尿病青年人群糖化血红蛋白（HbA1c）水平与蛋白尿之间的关联。材料与方法 本横断面研究共纳入537名肥胖的非糖尿病青年人群，该研究经瑞金医院伦理委员会批准。蛋白尿定义为尿白蛋白与肌酐比值（ACR）≥30mg/g。采用多因素logistic回归分析HbA1c水平与蛋白尿之间的关联。结果 尿ACR随HbA1c水平三分位数的增加而逐渐升高（趋势P<0.05）。在对混杂因素进行校正后的logistic回归分析中，HbA1c水平与蛋白尿风险呈正相关。比较HbA1c水平最高三分位数（≥5.7%）与最低三分位数（≤5.3%）时，蛋白尿的校正比值比（OR）为3.72（95%置信区间[CI]，1.25-11.00；P=0.017）。此外，在完全校正模型中，HbA1c水平每增加1个标准差，蛋白尿风险增加（OR，1.73；95%CI，1.25-2.46）。结论 这些数据表明，在肥胖的非糖尿病青年人群中，HbA1c水平与蛋白尿独立相关。
