Nandi-Munshi Debika, Afkarian Maryam, Whitlock Kathryn B, Crandell Jamie L, Bell Ronny A, D'Agostino Ralph, Saydah Sharon, Mottl Amy K, Dabelea Dana, Black Mary Helen, Mayer-Davis Elizabeth J, Pihoker Catherine
Department of Pediatrics, University of Washington, Seattle, Washington, USA.
Nephrology Division, Department of Medicine, University of California, Davis, California, USA.
Horm Res Paediatr. 2017;87(6):385-395. doi: 10.1159/000475711. Epub 2017 May 29.
BACKGROUND/AIMS: In adults, lower vitamin D has been associated with increased albuminuria. This association has not been extensively studied in youth with or without type 1 diabetes.
We examined the cross-sectional association between vitamin D and albuminuria (urine albumin to creatinine ratio ≥30 mg/g) in 8,789 participants of the National Health and Nutrition Survey 2001-2006 (NHANES), who were 6-19 years old. Further, we examined the association between vitamin D and albuminuria in 938 participants from the SEARCH Nutritional Ancillary Study (SNAS), a longitudinal cohort of youth with type 1 diabetes.
Of the NHANES participants, 5.3, 19.5, and 53.7% had vitamin D levels <30, 50 and 80 nmol/L, respectively. Albuminuria was present in 12.8% and was more common in younger children, females, non-Hispanic whites, non-obese children, and children with hypertension. After adjustments, there was no association between vitamin D and albuminuria. Among the SNAS participants with type 1 diabetes, we also found no association between baseline vitamin D and subsequent albuminuria in unadjusted or adjusted analyses.
We did not find an association between serum vitamin D and albuminuria in either non-diabetic youth or those with type 1 diabetes. Further research is needed to more fully understand this relationship.
背景/目的：在成年人中，维生素D水平较低与蛋白尿增加有关。在患有或未患有1型糖尿病的青少年中，这种关联尚未得到广泛研究。
我们在2001 - 2006年国家健康与营养检查调查（NHANES）的8789名6 - 19岁参与者中，研究了维生素D与蛋白尿（尿白蛋白与肌酐比值≥30 mg/g）之间的横断面关联。此外，我们在SEARCH营养辅助研究（SNAS）的938名参与者中研究了维生素D与蛋白尿之间的关联，该研究是一个1型糖尿病青少年的纵向队列。
在NHANES参与者中，维生素D水平<30、50和80 nmol/L的分别占5.3%、19.5%和53.7%。蛋白尿的发生率为12.8%，在年幼儿童、女性、非西班牙裔白人、非肥胖儿童和高血压儿童中更为常见。经过调整后，维生素D与蛋白尿之间没有关联。在患有1型糖尿病的SNAS参与者中，在未调整或调整后的分析中，我们也未发现基线维生素D与随后的蛋白尿之间存在关联。
我们在非糖尿病青少年或1型糖尿病青少年中均未发现血清维生素D与蛋白尿之间存在关联。需要进一步研究以更全面地了解这种关系。
